Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11178712 | 0.88 | POLB (0.55) | POLBHSD17B10TSHRGAAALDH1A1 | |
| SCHEMBL10356773 | 0.84 | MCHR1 (0.55) | POLBHSD17B10TSHRMAPTMCHR1 | |
| SCHEMBL11194691 | 0.84 | POLB (0.52) | POLBHDAC1HDAC8HDAC6HSD17B10 | |
| SCHEMBL11198118 | 0.84 | POLB (0.54) | POLBHSD17B10TSHRGAAALDH1A1 | |
| SCHEMBL11165531 | 0.84 | MCHR1 (0.55) | POLBHSD17B10TSHRMAPTMCHR1 | |
| SCHEMBL11200220 | 0.84 | POLB (0.54) | POLBHSD17B10TSHRGAAALDH1A1 | |
| SCHEMBL11165965 | 0.84 | MCHR1 (0.55) | POLBHSD17B10TSHRMAPTMCHR1 | |
| SCHEMBL11441498 | 0.83 | MCHR1 (0.56) | POLBGAAMAPTMCHR1RAB9A | |
| SCHEMBL11442018 | 0.81 | ALDH1A1 (0.55) | POLBHSD17B10TSHRGAAALDH1A1 | |
| SCHEMBL11302230 | 0.81 | MCHR1 (0.60) | POLBMAPTMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0023569-B1 | DERIVATIVES OF CARBOXYLIC ACIDS, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1983-06-22 | — | — | EP | disclosed |
| EP-0023569-A1 | Derivatives of carboxylic acids, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1981-02-11 | — | — | EP | disclosed |