Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 4/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LPAR3 | Q9UBY5 | 6/20 | 0.32 |
| ▸ | LPAR2 | Q9HBW0 | 5/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | TERT | O14746 | 1/20 | 0.31 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4558155 | 0.98 | GBA1 (0.40) | GBA1EPHX2ALDH1A1TDP1LPAR3 | |
| SCHEMBL7843304 | 0.98 | GBA1 (0.40) | GBA1EPHX2ALDH1A1TDP1LPAR3 | |
| SCHEMBL4388734 | 0.98 | GBA1 (0.40) | GBA1EPHX2ALDH1A1TDP1LPAR3 | |
| SCHEMBL39230 | 0.98 | GBA1 (0.40) | GBA1EPHX2ALDH1A1TDP1LPAR3 | |
| SCHEMBL8416438 | 0.98 | GBA1 (0.40) | GBA1EPHX2ALDH1A1TDP1LPAR3 | |
| SCHEMBL8523388 | 0.96 | GBA1 (0.37) | GBA1EPHX2ALDH1A1TDP1LPAR3 | |
| Ether SCHEMBL8473922 | 0.92 | GBA1 (0.36) | GBA1EPHX2ALDH1A1TDP1LPAR3 | |
| SCHEMBL12214257 | 0.91 | GAA (0.33) | GBA1EPHX2RECQLGAA | |
| SCHEMBL19845811 | 0.91 | GAA (0.35) | GAA | |
| SCHEMBL19834225 | 0.91 | GAA (0.35) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE31343-E | STABILIZERS FOR POLYMERS | CIBA-GEIGY CORPORATION (US) | 1983-08-09 | — | — | US | disclosed |
| US-RE31342-E | STABILIZERS FOR POLYMERS | CIBA-GEIGY CORPORATION (US) | 1983-08-09 | — | — | US | disclosed |