Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11173942 | 0.82 | HTR2A (0.55) | GPR84HTR2ATRPM8IDO1HTR1A | |
| SCHEMBL5897571 | 0.81 | HRH3 (0.60) | GPR84HTR2AIDO1HTR1AHRH3 | |
| SCHEMBL17829924 | 0.81 | GPR84 (0.54) | GPR84HTR2ATRPM8IDO1CSNK2A1 | |
| SCHEMBL11180317 | 0.79 | GPR84 (0.63) | GPR84HTR2ATRPM8HTR1AHTR1D | |
| SCHEMBL31415110 | 0.78 | GPR84 (0.72) | GPR84HTR2ATRPM8IDO1CSNK2A1 | |
| SCHEMBL28547448 | 0.77 | GPR84 (0.75) | GPR84HTR2ATRPM8IDO1CSNK2A1 | |
| SCHEMBL28972158 | 0.77 | RAB9A (0.52) | GPR84HTR2ATRPM8IDO1CSNK2A1 | |
| SCHEMBL3783656 | 0.76 | HTR2A (0.65) | GPR84HTR2ATRPM8CSNK2A1HTR1A | |
| SCHEMBL12903067 | 0.76 | GPR84 (0.63) | GPR84HTR2ATRPM8IDO1CSNK2A1 | |
| SCHEMBL5430044 | 0.76 | HTR2A (0.80) | GPR84HTR2ATRPM8IDO1CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4372887-A | DIURETIC, ANTITHROMBOGENIC, SMOOTH MUSCLE RELAXANTS | MEAD JOHNSON & COMPANY (US) | 1983-02-08 | — | — | US | disclosed |
| US-4259238-A | ANTIARRHYTHMIA AGENTS | MEAD JOHNSON & COMPANY (US) | 1981-03-31 | — | — | US | disclosed |
| US-4196212-A | DIURETIC, ANTITHROMBOGENIC, SMOOTH MUSCLE RELAXANT, ANTIINFLAMMATORY | MEAD JOHNSON & COMPANY (US) | 1980-04-01 | — | — | US | disclosed |
| US-4072675-A | DIURETICS, ANTICOAGULANTS, INOTROPIC AGENTS, ANTIINFLAMMATORY AGENTS, ANTIARRHYTHMIA AGENTS | MEAD JOHNSON & COMPANY (US) | 1978-02-07 | — | — | US | disclosed |
| US-4049714-A | DIURETIC, ANTITHROMBOGENIC, ANTIARRYTHMIC, ANTIINFLAMMATORY, MUSCLE RELAXANTS | MEAD JOHNSON & COMPANY (US) | 1977-09-20 | — | — | US | disclosed |