Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 7/20 | 0.40 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.38 |
| ▸ | SLC46A1 | Q96NT5 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.37 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.37 |
| ▸ | USP5 | P45974 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11180502 | 1.00 | FOLH1 (0.40) | FOLH1FOLR1SLC46A1KDM4EMAPT | |
| SCHEMBL28129663 | 0.86 | FOLH1 (0.47) | FOLH1KDM4EMAPTLMNACYP1A2 | |
| SCHEMBL28129661 | 0.86 | FOLH1 (0.47) | FOLH1KDM4EMAPTLMNACYP1A2 | |
| SCHEMBL28907590 | 0.84 | KDM4E (0.38) | FOLH1FOLR1SLC46A1KDM4EMAPT | |
| SCHEMBL6304327 | 0.83 | LMNA (0.37) | FOLR1SLC46A1KDM4EMAPTHIF1A | |
| SCHEMBL15905074 | 0.82 | FOLH1 (0.38) | FOLH1FOLR1SLC46A1CA2CA1 | |
| SCHEMBL27805530 | 0.78 | TRPM8 (0.44) | FOLH1MAPTLMNACYP1A2HDAC6 | |
| Zinc Ion SCHEMBL11176430 | 0.77 | FOLH1 (0.46) | FOLH1PHLPP2LMNACYP1A2CYP3A4 | |
| Zinc Ion SCHEMBL11176433 | 0.77 | FOLH1 (0.46) | FOLH1PHLPP2LMNACYP1A2CYP3A4 | |
| SCHEMBL10656927 | 0.77 | FOLH1 (0.46) | FOLH1PHLPP2LMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4374987-A | FROM 2,4,5,6-TETRAMINOPYRIMIDINE SULFATE, 1,1,3-TRIBROMOACETONE AND A ZINC P-AMINOBENZOYLGLUTAMATE | AMERICAN CYANAMID COMPANY (US) | 1983-02-22 | — | — | US | disclosed |