Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 10/20 | 0.39 |
| ▸ | CA1 | P00915 | 9/20 | 0.39 |
| ▸ | CA9 | Q16790 | 8/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA3 | P07451 | 2/20 | 0.34 |
| ▸ | CA4 | P22748 | 2/20 | 0.34 |
| ▸ | CA6 | P23280 | 2/20 | 0.34 |
| ▸ | CA5A | P35218 | 2/20 | 0.34 |
| ▸ | CA7 | P43166 | 2/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29018668 | 0.98 | CA2 (0.38) | CA2CA1CA9KDM4EUSP2 | |
| SCHEMBL26981905 | 0.98 | CA2 (0.38) | CA2CA1CA9KDM4EUSP2 | |
| SCHEMBL16148467 | 0.98 | CA2 (0.38) | CA2CA1CA9KDM4EUSP2 | |
| SCHEMBL1118353 | 0.93 | CA2 (0.40) | CA2CA1CA9KDM4EUSP2 | |
| SCHEMBL575713 | 0.89 | CA2 (0.44) | CA2CA1CA9KDM4EUSP2 | |
| SCHEMBL23291930 | 0.86 | CA2 (0.46) | CA2CA1CA9KDM4EUSP2 | |
| SCHEMBL14779178 | 0.86 | CA2 (0.46) | CA2CA1CA9KDM4EUSP2 | |
| SCHEMBL2735589 | 0.86 | CA2 (0.46) | CA2CA1CA9KDM4EUSP2 | |
| SCHEMBL8398329 | 0.86 | CA2 (0.46) | CA2CA1CA9KDM4EUSP2 | |
| SCHEMBL4952312 | 0.86 | CA2 (0.46) | CA2CA1CA9KDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11634449-B2 | Macrolides and methods of their preparation and use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-04-25 | — | — | US | disclosed |
| EP-4095146-A1 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | President And Fellows Of Harvard College (US) | 2022-11-30 | — | — | EP | disclosed |
| US-20220332747-A1 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2022-10-20 | — | — | US | disclosed |
| EP-2988597-B1 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | HARVARD COLLEGE (US) | 2022-06-08 | — | — | EP | disclosed |
| US-10913764-B2 | Macrolides and methods of their preparation and use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-02-09 | — | — | US | disclosed |
| CN-111825733-A | Macrolides and methods of making and using the same | 哈佛大学的校长及成员们 | 2020-10-27 | — | — | CN | disclosed |
| WO-2019032961-A1 | TRIOXACARCIN-ANTIBODY CONJUGATES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-02-14 | — | — | WO | disclosed |
| US-20180298048-A1 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-10-18 | — | — | US | disclosed |
| US-9982005-B2 | Macrolides and methods of their preparation and use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-05-29 | — | — | US | disclosed |
| EP-2988597-A2 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | President and Fellows of Harvard College (US) | 2016-03-02 | — | — | EP | disclosed |
| US-20160052951-A1 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-02-25 | — | — | US | disclosed |
| CN-105246334-A | Macrolides and methods of making and using the same | HARVARD COLLEGE | 2016-01-13 | — | — | CN | disclosed |
| WO-2014165792-A2 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-10-09 | — | — | WO | disclosed |
| CN-102036943-A | Preparation of a catalyst containing CF3Method for preparing compounds of O group | MERCK PATENT GMBH | 2011-04-27 | — | — | CN | disclosed |
| US-20110082312-A1 | PRODUCTION OF COMPOUNDS COMPRISING CF30 GROUPS | MERCK PATENT GESELLSCHAFT MIT DESCHRANKTER HAFTUNG (DE) | 2011-04-07 | — | — | US | disclosed |
| US-20110082312-A1 | PRODUCTION OF COMPOUNDS COMPRISING CF30 GROUPS | MERCK PATENT GESELLSCHAFT MIT DESCHRANKTER HAFTUNG (DE) | 2011-04-07 | — | — | US | disclosed |
| US-20110082312-A1 | PRODUCTION OF COMPOUNDS COMPRISING CF30 GROUPS | MERCK PATENT GESELLSCHAFT MIT DESCHRANKTER HAFTUNG (DE) | 2011-04-07 | — | — | US | disclosed |
| EP-2280918-A1 | PRODUCTION OF COMPOUNDS COMPRISING CF3O GROUPS | Merck Patent GmbH (DE) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009141053-A1 | PRODUCTION OF COMPOUNDS COMPRISING CF3O GROUPS | MERCK PATENT GMBH, (DE) | 2009-11-26 | — | — | WO | disclosed |
| WO-2009141053-A1 | PRODUCTION OF COMPOUNDS COMPRISING CF3O GROUPS | MERCK PATENT GMBH, (DE) | 2009-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110082312-A1 | PRODUCTION OF COMPOUNDS COMPRISING CF30 GROUPS | ZRANB2, ORC3, IKZF2 | CA2 2082/4885CA1 3331/4885CA9 1296/4885 |
| US-20220332747-A1 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | CYP11B2, ERG28, DHCR7 | CA2 4851/4885CA1 4869/4885CA9 4601/4885 |
| US-20160052951-A1 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | CYP11B2, ERG28, DHCR7 | CA2 4851/4885CA1 4869/4885CA9 4601/4885 |
| US-11634449-B2 | Macrolides and methods of their preparation and use | CYP11B2, ERG28, DHCR7 | CA2 4851/4885CA1 4869/4885CA9 4601/4885 |
| US-10913764-B2 | Macrolides and methods of their preparation and use | CYP11B2, ERG28, DHCR7 | CA2 4851/4885CA1 4869/4885CA9 4601/4885 |
| US-20180298048-A1 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | CYP11B2, ERG28, DHCR7 | CA2 4851/4885CA1 4869/4885CA9 4601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.