Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CNR1 | P21554 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11182289 | 0.91 | KDM4E (0.56) | KDM4EALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11185202 | 0.87 | KDM4E (0.53) | KDM4EALDH1A1CNR1RAB9ANPC1 | |
| SCHEMBL11184274 | 0.87 | CNR1 (0.53) | KDM4EALDH1A1CNR1SMN1; SMN2KMT2A | |
| SCHEMBL11182832 | 0.86 | KDM4E (0.52) | KDM4EALDH1A1CNR1RAB9ANPC1 | |
| SCHEMBL11186543 | 0.85 | ALDH1A1 (0.54) | KDM4EALDH1A1CNR1RAB9ANPC1 | |
| SCHEMBL11187742 | 0.84 | CNR1 (0.49) | KDM4EALDH1A1CNR1RAB9ANPC1 | |
| Maleic Acid SCHEMBL11184890 | 0.82 | KDM4E (0.48) | KDM4EALDH1A1CNR1RAB9ANPC1 | |
| Fumaric Acid SCHEMBL11184896 | 0.82 | KDM4E (0.48) | KDM4EALDH1A1CNR1RAB9ANPC1 | |
| SCHEMBL11189341 | 0.81 | PKM (0.57) | KDM4EALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11184284 | 0.79 | KDM4E (0.57) | KDM4EALDH1A1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4420619-A | Imidazole urea and amido compounds | CIBA-GEIGY CORPORATION (US) | 1983-12-13 | — | — | US | disclosed |
| US-4292429-A | Imidazole urea and amido compounds | CIBA-GEIGY CORPORATION (US) | 1981-09-29 | — | — | US | disclosed |