Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11203014 | 0.88 | SMN1; SMN2 (0.40) | HPGDMAPTNPSR1ALOX15TSHR | |
| SCHEMBL11198001 | 0.85 | MAPT (0.47) | HPGDMAPTNPSR1PDE4BRAB9A | |
| SCHEMBL11201372 | 0.81 | SRD5A2 (0.45) | HPGDNPSR1ALOX15TSHRCYP1A2 | |
| SCHEMBL11201124 | 0.80 | HPGD (0.43) | HPGDMAPTPTGS2ABCB11NPSR1 | |
| SCHEMBL7678013 | 0.79 | HPGD (0.45) | HPGDMAPTPTGS2ABCB11NPSR1 | |
| SCHEMBL11197629 | 0.78 | MEN1 (0.36) | MAPTTSHRPDE4APDE4BPDE4C | |
| SCHEMBL11201468 | 0.78 | MAPT (0.41) | HPGDMAPTPTGS2ABCB11NPSR1 | |
| SCHEMBL11194810 | 0.75 | LMNA (0.43) | HPGDMAPTNPSR1ALOX15TSHR | |
| SCHEMBL8606636 | 0.74 | ALDH1A1 (0.46) | HPGDMAPTPTGS2SRD5A2PTGS1 | |
| SCHEMBL11193533 | 0.73 | KMT2A (0.38) | HPGDMAPTPTGS2NPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0072013-A1 | Pyrrole compounds as anti-inflammatory and analgesic agents | MERCK & CO. INC. (US) | 1983-02-16 | — | — | EP | claimed |
| EP-0072013-A1 | Pyrrole compounds as anti-inflammatory and analgesic agents | MERCK & CO. INC. (US) | 1983-02-16 | — | — | EP | disclosed |