SCHEMBL11197828

SCHEMBL11197828

Cc1ccc(CBr)c(C)c1C(=O)O

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.36
TDP1 Q9NUW8 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
METAP2 P50579 6/20 0.35
LDHA P00338 3/20 0.35
LDHB P07195 3/20 0.35
NOTUM Q6P988 1/20 0.34
KDM4E B2RXH2 1/20 0.33
CYP3A4 P08684 1/20 0.33
ACHE P22303 1/20 0.33
DHODH Q02127 1/20 0.33
PDE10A Q9Y233 1/20 0.33
MCL1 Q07820 1/20 0.33
POLB P06746 1/20 0.32
RECQL P46063 1/20 0.32
ALDH1A1 P00352 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27671375 0.85 METAP2 (0.37) L3MBTL1TDP1SMN1; SMN2METAP2LDHA
SCHEMBL10456939 0.84 METAP2 (0.47) L3MBTL1TDP1SMN1; SMN2METAP2LDHA
SCHEMBL15957663 0.82 METAP2 (0.48) L3MBTL1TDP1SMN1; SMN2METAP2LDHA
SCHEMBL14783306 0.81 L3MBTL1 (0.36) L3MBTL1TDP1SMN1; SMN2METAP2LDHA
SCHEMBL8923355 0.81 SMN1; SMN2 (0.50) L3MBTL1TDP1SMN1; SMN2KDM4ECYP3A4
SCHEMBL8793515 0.81 PON1 (0.39) L3MBTL1TDP1SMN1; SMN2METAP2LDHA
Hydrochloric Acid SCHEMBL27837550 0.79 L3MBTL1 (0.35) L3MBTL1TDP1SMN1; SMN2METAP2LDHA
SCHEMBL6122759 0.79 NOTUM (0.33) L3MBTL1TDP1SMN1; SMN2LDHALDHB
SCHEMBL1686189 0.79 CA12 (0.47) TDP1SMN1; SMN2KDM4ECYP3A4POLB
SCHEMBL28931615 0.78 TAAR1 (0.43) L3MBTL1TDP1SMN1; SMN2METAP2LDHA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3303415-B1 VISIBLE-LIGHT PHOTOINITIATORS AND USES THEREOF ALCON INC (CH) 2022-12-28 EP disclosed
US-10324311-B2 Visible-light photoinitiators and uses thereof NOVARTIS AG (CH) 2019-06-18 US disclosed
EP-3303415-A1 VISIBLE-LIGHT PHOTOINITIATORS AND USES THEREOF Novartis AG (CH) 2018-04-11 EP disclosed
US-20160357031-A1 VISIBLE-LIGHT PHOTOINITIATORS AND USES THEREOF ALCON INC. (CH) 2016-12-08 US disclosed
WO-2016193912-A1 VISIBLE-LIGHT PHOTOINITIATORS AND USES THEREOF NOVARTIS AG (CH) 2016-12-08 WO disclosed
US-4409227-A HYPOGLYCEMIC AGENTS THE DOW CHEMICAL CO. (US) 1983-10-11 US disclosed
US-4325959-A Hypoglycemic 4-(((1,3,4, thiadiazolyl)thio)methyl)benzoic acids, ester and amides THE DOW CHEMICAL COMPANY (US) 1982-04-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10324311-B2 Visible-light photoinitiators and uses thereof SIRT5, IK, IGLV6-57 L3MBTL1 1275/4885TDP1 4374/4885SMN1; SMN2 4875/4885
US-20160357031-A1 VISIBLE-LIGHT PHOTOINITIATORS AND USES THEREOF SIRT5, IK, IGLV6-57 L3MBTL1 1275/4885TDP1 4374/4885SMN1; SMN2 4875/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.