Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 known ✓ | P08588 | 3/20 | 0.44 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.43 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.43 |
| ▸ | HTR3A known ✓ | P46098 | 2/20 | 0.43 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.43 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.43 |
| ▸ | HTR3B | O95264 | 2/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11199816 | 0.88 | CRBN (0.52) | CRBNDDB1ADRB1NPC1MAPK13 | |
| SCHEMBL7274510 | 0.87 | CRBN (0.53) | CRBNDDB1ADRB1NPC1MAPK13 | |
| SCHEMBL18553768 | 0.78 | SMN1; SMN2 (0.67) | HTR6 | |
| Bromide SCHEMBL9825246 | 0.78 | MAPKAPK2 (0.52) | ADRB1 | |
| SCHEMBL16318342 | 0.77 | ADRB1 (0.44) | ADRB1HTR6HTR3EHTR3BHTR1A | |
| SCHEMBL7685717 | 0.76 | ADRB1 (0.50) | DRD2ADRB1HTR6HTR3EHTR3B | |
| SCHEMBL9824743 | 0.76 | MAPKAPK2 (0.53) | ADRB1 | |
| SCHEMBL11202917 | 0.74 | PDE3B (0.57) | DRD2SLC6A4HTR2A | |
| SCHEMBL22728530 | 0.73 | CRBN (0.49) | CRBNCA9DRD2NPC1MAPK13 | |
| SCHEMBL29489689 | 0.73 | CRBN (0.49) | CRBNCA9DRD2NPC1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4415572-A | CARDIOTONIC AND INOTROPIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1983-11-15 | — | — | US | disclosed |