Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.51 |
| ▸ | ADRB1 known ✓ | P08588 | 3/20 | 0.44 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.43 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.43 |
| ▸ | HTR3A known ✓ | P46098 | 2/20 | 0.43 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.52 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274510 | 0.98 | CRBN (0.53) | CRBNPDE3BPDE3ATBXAS1SLC6A4 | |
| Bromide SCHEMBL11198697 | 0.88 | CRBN (0.52) | CRBNSLC6A4DDB1ADRB1NPC1 | |
| Bromide SCHEMBL9825246 | 0.87 | MAPKAPK2 (0.52) | MAPKAPK2ADRB1 | |
| SCHEMBL9824743 | 0.85 | MAPKAPK2 (0.53) | MAPKAPK2ADRB1 | |
| SCHEMBL8880352 | 0.83 | CRBN (0.53) | CRBNPDE3BPDE3ATBXAS1SLC6A4 | |
| SCHEMBL11196268 | 0.82 | CRBN (0.52) | CRBNPDE3BPDE3ATBXAS1SLC6A4 | |
| SCHEMBL8807339 | 0.80 | SLC6A4 (0.52) | CRBNPDE3BPDE3ATBXAS1SLC6A4 | |
| Hydrochloric Acid SCHEMBL7286588 | 0.79 | SMYD3 (0.50) | CRBNPDE3BPDE3ATBXAS1SLC6A4 | |
| SCHEMBL11197711 | 0.78 | PDE3B (0.53) | CRBNPDE3BPDE3ATBXAS1SLC6A4 | |
| SCHEMBL11194801 | 0.78 | SLC6A4 (0.64) | CRBNPDE3BPDE3ATBXAS1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4415572-A | CARDIOTONIC AND INOTROPIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1983-11-15 | — | — | US | disclosed |