Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.48 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.48 |
| ▸ | SCD | O00767 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11148451 | 0.86 | NPC1 (0.45) | ALDH1A1LMNAMAPTHPGDNPC1 | |
| SCHEMBL11200589 | 0.86 | NPC1 (0.43) | ALDH1A1LMNAMAPTHPGDNPC1 | |
| SCHEMBL11148448 | 0.84 | HTT (0.46) | LMNAMAPTHPGDNPC1RAB9A | |
| SCHEMBL11208407 | 0.83 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTHPGDNPC1 | |
| SCHEMBL11192028 | 0.83 | HPGDS (0.52) | ALDH1A1LMNAMAPTNPC1RAB9A | |
| SCHEMBL9775626 | 0.83 | RAB9A (0.49) | ALDH1A1LMNAMAPTHPGDNPC1 | |
| SCHEMBL9775616 | 0.82 | RAB9A (0.50) | LMNAMAPTHPGDNPC1RAB9A | |
| SCHEMBL9775604 | 0.81 | RAB9A (0.49) | ALDH1A1LMNAMAPTHPGDNPC1 | |
| SCHEMBL11200852 | 0.81 | NPC1 (0.51) | ALDH1A1LMNAMAPTNPC1RAB9A | |
| SCHEMBL9775653 | 0.79 | MEN1 (0.46) | ALDH1A1LMNAMAPTHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4299831-A | 2-Trifluoromethyl-3-quinoline carboxamides, analgesic and anti-inflammatory compositions and methods employing them | ROUSSEL UCLAF (FR) | 1981-11-10 | — | — | US | claimed |
| EP-0012639-B1 | QUINOLEIN-3-CARBOXYLIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE IN MEDICINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1983-09-07 | — | — | EP | disclosed |
| US-4299831-A | 2-Trifluoromethyl-3-quinoline carboxamides, analgesic and anti-inflammatory compositions and methods employing them | ROUSSEL UCLAF (FR) | 1981-11-10 | — | — | US | disclosed |
| EP-0012639-A2 | Quinolein-3-carboxylic acid derivatives, process for their preparation, their use in medicines and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1980-06-25 | — | — | EP | disclosed |