Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 20/20 | 0.66 |
| ▸ | OPRL1 | P41146 | 14/20 | 0.66 |
| ▸ | OGFRL1 | Q5TC84 | 9/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1119615 | 0.89 | OPRM1 (0.70) | OPRM1OPRL1OGFRL1OPRD1OPRK1 | |
| Citric Acid SCHEMBL2198497 | 0.88 | OPRM1 (0.54) | OPRM1OPRL1OGFRL1OPRD1OPRK1 | |
| SCHEMBL16673308 | 0.85 | OPRM1 (0.54) | OPRM1OPRL1OGFRL1OPRD1OPRK1 | |
| SCHEMBL3407050 | 0.85 | OPRM1 (0.80) | OPRM1OPRL1OGFRL1OPRD1OPRK1 | |
| SCHEMBL3411311 | 0.81 | OPRM1 (0.74) | OPRM1OPRL1OGFRL1OPRD1OPRK1 | |
| SCHEMBL15642831 | 0.81 | OPRM1 (0.74) | OPRM1OPRL1OGFRL1OPRD1OPRK1 | |
| SCHEMBL3406064 | 0.80 | OPRM1 (1.00) | OPRM1OPRL1OGFRL1OPRD1OPRK1 | |
| SCHEMBL3411382 | 0.78 | OPRM1 (0.77) | OPRM1OPRL1OGFRL1OPRD1OPRK1 | |
| SCHEMBL3411645 | 0.77 | OPRM1 (0.74) | OPRM1OPRL1OGFRL1OPRD1OPRK1 | |
| SCHEMBL3413563 | 0.77 | OPRM1 (0.80) | OPRM1OPRL1OGFRL1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280941-B1 | (HETERO-)ARYL CYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2015-05-06 | — | — | EP | claimed |
| US-7977370-B2 | (Hetero)aryl cyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2011-07-12 | — | — | US | claimed |
| EP-2280941-A1 | (HETERO-)ARYL CYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2011-02-09 | — | — | EP | claimed |
| WO-2009118163-A1 | (HETERO-)ARYL CYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2009-10-01 | — | — | WO | claimed |
| US-20090247573-A1 | (HETERO)ARYL CYCLOHEXANE DERIVATIVES | GRUNENTHAL GMBH (DE) | 2009-10-01 | — | — | US | claimed |
| EP-2280941-B1 | (HETERO-)ARYL CYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2015-05-06 | — | — | EP | disclosed |
| US-7977370-B2 | (Hetero)aryl cyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2011-07-12 | — | — | US | disclosed |
| EP-2280941-A1 | (HETERO-)ARYL CYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009118163-A1 | (HETERO-)ARYL CYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2009-10-01 | — | — | WO | disclosed |
| US-20090247573-A1 | (HETERO)ARYL CYCLOHEXANE DERIVATIVES | GRUNENTHAL GMBH (DE) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247573-A1 | (HETERO)ARYL CYCLOHEXANE DERIVATIVES | OPRL1, OPRM1, OPRD1 | OPRM1 2/4885OPRL1 1/4885OGFRL1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.