Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11197536 | 0.92 | NR3C1 (0.64) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| SCHEMBL11192867 | 0.85 | KCNH2 (0.58) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| SCHEMBL11202917 | 0.85 | PDE3B (0.57) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| SCHEMBL11043236 | 0.84 | SIRT2 (0.55) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| SCHEMBL11194496 | 0.83 | NR3C1 (0.62) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| SCHEMBL11201034 | 0.82 | NR3C1 (0.66) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| SCHEMBL16026508 | 0.79 | ALDH1A1 (0.70) | SMN1; SMN2ALDH1A1MAPTCRHBPCRHR2 | |
| SCHEMBL11197452 | 0.78 | ALDH1A1 (0.60) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| SCHEMBL8495619 | 0.78 | PDE3B (0.85) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| SCHEMBL11196470 | 0.78 | SMN1; SMN2 (0.56) | NR3C1PGRSLC6A4KCNH2PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4415572-A | CARDIOTONIC AND INOTROPIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1983-11-15 | — | — | US | disclosed |