Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.53 |
| ▸ | HTR2C | P28335 | 7/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11202115 | 0.92 | SIRT1 (0.50) | HTR2AHTR2CSIRT1PIM1CLK4 | |
| SCHEMBL11202961 | 0.88 | NR1H2 (0.46) | HTR2AHTR2CSIRT1HTR6KMT2A | |
| SCHEMBL11199918 | 0.87 | PIM1 (0.49) | HTR2AHTR2CSIRT1PIM1CLK4 | |
| SCHEMBL11199712 | 0.84 | HTR2A (0.52) | HTR2AHTR2CHTR6NR2E1DRD2 | |
| SCHEMBL20601973 | 0.84 | MAPT (0.54) | SIRT1CLK4HTR6NR2E1DRD2 | |
| SCHEMBL11203137 | 0.84 | RB1 (0.51) | SIRT1HTR6NR2E1DRD2DRD1 | |
| SCHEMBL11199139 | 0.84 | HTR1D (0.57) | HTR2AHTR2CSIRT1HTR6KMT2A | |
| SCHEMBL11204594 | 0.84 | NR2E1 (0.57) | HTR2AHTR2CNR2E1DRD2DRD1 | |
| SCHEMBL7048004 | 0.83 | NR2E1 (0.63) | HTR2AHTR2CCLK4NR2E1DRD2 | |
| SCHEMBL11197826 | 0.81 | HTR1D (0.66) | HTR2AHTR2CSIRT1HTR6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0073849-A1 | Novel phenyl-1,2,3,4-tetrahydrocarbazoles, their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1983-03-16 | — | — | EP | disclosed |
| US-4292323-A | Phenyl-1,2,3,4-tetrahydrocarbazoles and use thereof | SCHERING CORPORATION (US) | 1981-09-29 | — | — | US | disclosed |