Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.50 |
| ▸ | HTR2A | P28223 | 6/20 | 0.44 |
| ▸ | HTR2C | P28335 | 6/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.44 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.44 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11199918 | 0.92 | PIM1 (0.49) | SIRT1HTR2AHTR2CBAZ2BPIM1 | |
| SCHEMBL11200910 | 0.92 | HTR2A (0.53) | SIRT1HTR2AHTR2CBAZ2BPIM1 | |
| SCHEMBL11199139 | 0.89 | HTR1D (0.57) | SIRT1HTR2AHTR2CKMT2AALOX15 | |
| SCHEMBL11204182 | 0.86 | HTR1D (0.63) | HTR2AHTR2CBAZ2BKMT2AMAPT | |
| SCHEMBL11204594 | 0.86 | NR2E1 (0.57) | HTR2AHTR2CKMT2AMAPTMEN1 | |
| SCHEMBL11202961 | 0.85 | NR1H2 (0.46) | SIRT1HTR2AHTR2CBAZ2BKMT2A | |
| SCHEMBL23657201 | 0.80 | KMT2A (0.64) | SIRT1HTR2AHTR2CBAZ2BKMT2A | |
| SCHEMBL6529419 | 0.80 | HTR1B (0.65) | SIRT1BAZ2BKMT2AHTR1BHTR1D | |
| SCHEMBL7409510 | 0.80 | SIRT1 (0.55) | SIRT1BAZ2BKMT2AMAPTALOX15 | |
| SCHEMBL6529421 | 0.80 | HTR1B (0.65) | SIRT1BAZ2BKMT2AHTR1BHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0073849-A1 | Novel phenyl-1,2,3,4-tetrahydrocarbazoles, their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1983-03-16 | — | — | EP | disclosed |