Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1120121 | 1.00 | CA1 (0.40) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL8967450 | 0.71 | CES1 (0.43) | CES2CES1AKR1B1KMT2ATSHR | |
| SCHEMBL14194428 | 0.70 | CES2 (0.41) | CES2CES1AKR1B1KMT2AMEN1 | |
| SCHEMBL11131330 | 0.70 | CYP1A1 (0.42) | CES2CES1AKR1B1KMT2ATSHR | |
| SCHEMBL4373160 | 0.69 | MAPT (0.41) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL4373163 | 0.69 | MAPT (0.41) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL3241398 | 0.67 | PRSS1 (0.50) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL1457443 | 0.67 | CA1 (0.54) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL8479057 | 0.66 | PRSS1 (0.41) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL7594223 | 0.65 | PRSS1 (0.52) | CA1CA2MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130395-A1 | INHIBITORS OF FLIP TO TREAT CANCER | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2011-10-20 | — | — | WO | disclosed |
| US-20110251135-A1 | INHIBITORS OF PERITONEAL SEEDING OF CANCER CELLS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2011-10-13 | — | — | US | disclosed |
| US-7989495-B2 | 3-Sulfonyl propenenitriles, e.g., BAY 11-7085 (3-(t-butylphenylsulfonyl)-2-propenenitrile; promoting apoptosis and inhibiting readhesion of cancer cells; antimetastasis agents, particularly for hepatic, parietal or peritoneal area; inhibiting tumorigenesis; antiproliferative agents (not for myeloma) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2011-08-02 | — | — | US | disclosed |
| EP-2281077-A2 | INHIBITORS OF PERITONEAL SEEDING OF CANCER CELLS | University of Utah Research Foundation (US) | 2011-02-09 | — | — | EP | disclosed |
| US-20050124590-A1 | Compositions and methods for inhibiting nf-kappab mediated tumorigenicity and adhesion dependent survival of cancer cells | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124590-A1 | Compositions and methods for inhibiting nf-kappab mediated tumorigenicity and adhesion dependent survival of cancer cells | NFKBIA, RELA, NFKB1 | CA1 1475/4885CA2 3319/4885MMP1 461/4885 |
| US-20110251135-A1 | INHIBITORS OF PERITONEAL SEEDING OF CANCER CELLS | NFKBIA, IKBKB, RELA | CA1 872/4885CA2 2897/4885MMP1 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.