Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11196500 | 0.88 | NPSR1 (0.51) | NPSR1GAASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL5551453 | 0.84 | GAA (0.59) | NPSR1GAASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL1668484 | 0.84 | GAA (0.62) | NPSR1GAASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL23599248 | 0.84 | TDP1 (0.52) | NPSR1SMN1; SMN2TDP1L3MBTL1KDM4E | |
| SCHEMBL23582833 | 0.84 | LTA4H (0.54) | — | |
| SCHEMBL5202817 | 0.83 | GAA (0.66) | NPSR1GAASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL1107148 | 0.83 | GAA (0.70) | NPSR1GAASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL700166 | 0.83 | PARP10 (0.61) | TDP1KDM4EALDH1A1 | |
| SCHEMBL25902342 | 0.83 | GAA (0.57) | NPSR1GAASMN1; SMN2KDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL11371198 | 0.83 | GAA (0.60) | NPSR1GAASMN1; SMN2KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4387099-A | Alkanolamine derivatives | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1983-06-07 | — | — | US | disclosed |
| US-4327113-A | DRUGS FOR TREATMENT OF HEART DISEASES, ADRENERGIC BLOCKING AGENTS, ETC | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1982-04-27 | — | — | US | disclosed |
| US-4260632-A | ADRENERGIC BLOCKING AGENTS, CARDIOVASCULAR DISORDERS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-04-07 | — | — | US | disclosed |
| US-4221807-A | ADRENERGIC BLOCKING AGENTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-09-09 | — | — | US | disclosed |
| US-4141987-A | HYPOTENSIVE, ADRENERGIC BLOCKING AGENT | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1979-02-27 | — | — | US | disclosed |