Sugi Predict

Sugi Predict / Compounds / SCHEMBL5202817

SCHEMBL5202817

SCHEMBL5202817

CCOC(=O)COc1ccc(CC)cc1

nearest known ligand 0.72

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 2/20 0.66
▸ NPSR1 Q6W5P4 1/20 0.66
▸ KDM4E B2RXH2 2/20 0.54
▸ HSD17B10 Q99714 2/20 0.54
▸ ALDH1A1 P00352 1/20 0.54
▸ TP53 P04637 1/20 0.54
▸ MAPT P10636 1/20 0.54
▸ HPGD P15428 1/20 0.54
▸ POLB P06746 1/20 0.52
▸ RXFP1 Q9HBX9 1/20 0.52
▸ CYP1A2 P05177 1/20 0.51
▸ TBXAS1 P24557 1/20 0.51
▸ SMN1; SMN2 Q16637 1/20 0.51
▸ TSHR P16473 1/20 0.51
▸ PTPN1 P18031 1/20 0.50
▸ PPARG P37231 1/20 0.50
▸ PPARA Q07869 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8321862 0.88 GAA (0.64) GAANPSR1KDM4EHSD17B10ALDH1A1
SCHEMBL11815554 0.87 GAA (0.72) GAANPSR1KDM4EHSD17B10ALDH1A1
SCHEMBL12290360 0.87 GAA (0.51) GAANPSR1KDM4EALDH1A1POLB
SCHEMBL7228178 0.86 GAA (0.62) GAANPSR1KDM4EHSD17B10ALDH1A1
SCHEMBL7918868 0.86 GAA (0.62) GAANPSR1KDM4EHSD17B10ALDH1A1
SCHEMBL1668484 0.86 GAA (0.62) GAANPSR1KDM4EHSD17B10ALDH1A1
SCHEMBL14280334 0.85 HPGD (0.56) GAANPSR1KDM4EHSD17B10ALDH1A1
SCHEMBL1107148 0.85 GAA (0.70) GAANPSR1KDM4EHSD17B10ALDH1A1
SCHEMBL9267668 0.85 GAA (0.70) GAANPSR1KDM4EHSD17B10ALDH1A1
SCHEMBL11550281 0.85 GAA (0.70) GAANPSR1KDM4EHSD17B10ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110869365-B Cooling composition 弗门尼舍有限公司 2024-03-29 — — CN disclosed
EP-4197596-A1 IMIDAZOLE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF INFECTIOUS DISEASES Eberhard Karls Universität Tübingen Medizinische Fakultät (DE) 2023-06-21 — — EP disclosed
US-11174249-B2 Cooling composition FIRMENICH SA (CH) 2021-11-16 — — US disclosed
EP-3652171-B1 COOLING COMPOSITIONS CONTAINING AN AMIDE AND AN ALKYL LACTATE FIRMENICH & CIE (CH) 2021-09-08 — — EP disclosed
CN-108473484-B Compounds useful as TRPM8 modulators 弗门尼舍公司 2021-06-29 — — CN disclosed
EP-3356356-B1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED (US) 2021-05-26 — — EP disclosed
EP-3356356-B1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED (US) 2021-05-26 — — EP disclosed
US-10662180-B2 Proteasome chymotrypsin-like inhibition using PI-1833 analogs H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) 2020-05-26 — — US disclosed
US-10662180-B2 Proteasome chymotrypsin-like inhibition using PI-1833 analogs H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) 2020-05-26 — — US disclosed
US-20200157083-A1 COOLING COMPOSITION FIRMENICH SA (CH) 2020-05-21 — — US disclosed
WO-2012129564-A2 PROTEASOME CHYMOTRYPSIN-LIKE INHIBITION USING PI-1833 ANALOGS H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) 2012-09-27 — — WO disclosed
US-20110166088-A1 BENZOTHIAZOLES AND AZA-ANALOGUES THEREOF USE AS ANTIBACTERIAL AGENTS RANBAXY LABORATORIES LIMITED (IN) 2011-07-07 — — US disclosed
US-20090203676-A1 G-protein Coupled Receptor Agonists PROSIDION LIMITED (GB) 2009-08-13 — — US disclosed
EP-1165523-B1 NEUROTROPHIC SUBSTITUTED PYRIMIDINES KRENITSKY PHARMACEUTICALS INC (US) 2007-11-07 — — EP disclosed
US-7271270-B2 High affinity small molecule C5a receptor modulators NEUROGEN CORPORATION (US) 2007-09-18 — — US disclosed
US-6916820-B1 Neurotrophic substituted pyrimidines KRENITSKY PHARMACEUTICALS, INC. (US) 2005-07-12 — — US disclosed
US-6583148-B1 Neurodegenerative or other neurological disorders; enhancing the effect of nerve growth factor; 2-Amino-5-(4-chlorophenoxy)-4-trans-4-hydroxycyclohexylamino) pyrimidine KRENITSKY PHARMACEUTICALS, INC. 2003-06-24 — — US disclosed
EP-1165523-A1 NEUROTROPHIC SUBSTITUTED PYRIMIDINES Krenitsky Pharmaceuticals, Inc. (US) 2002-01-02 — — EP disclosed
WO-2000061562-A1 NEUROTROPHIC SUBSTITUTED PYRIMIDINES KRENITSKY PHARMACEUTICALS INC. (US) 2000-10-19 — — WO disclosed
US-3985791-A 16-Phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives SYNTEX (U.S.A.) INC. (US) 1976-10-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110166088-A1 BENZOTHIAZOLES AND AZA-ANALOGUES THEREOF USE AS ANTIBACTERIAL AGENTS TOP2B, TOP1, POLI GAA 100/4885NPSR1 4203/4885KDM4E 315/4885
US-20200157083-A1 COOLING COMPOSITION LDHA, LDHB, ADH1A GAA 2275/4885NPSR1 1276/4885KDM4E 4506/4885
US-10662180-B2 Proteasome chymotrypsin-like inhibition using PI-1833 analogs PSMB3, PSME3, PSMD3 GAA 771/4885NPSR1 4301/4885KDM4E 2332/4885
US-11174249-B2 Cooling composition LDHA, LDHB, ADH1A GAA 2275/4885NPSR1 1276/4885KDM4E 4506/4885
US-20090203676-A1 G-protein Coupled Receptor Agonists GPR119, GCGR, GPBAR1 GAA 1012/4885NPSR1 142/4885KDM4E 4578/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.