SCHEMBL11201640

SCHEMBL11201640

CS(=O)(=O)c1cccnc1Oc1cccc(C#N)c1

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CKS1B P61024 1/20 0.46
SKP2 Q13309 1/20 0.46
EPAS1 Q99814 7/20 0.45
VEGFA P15692 1/20 0.41
P2RY1 P47900 1/20 0.40
RAB9A P51151 1/20 0.39
CLK4 Q9HAZ1 1/20 0.39
GPR119 Q8TDV5 1/20 0.39
TDP2 O95551 1/20 0.39
HAO1 Q9UJM8 2/20 0.39
GLO1 Q04760 1/20 0.39
SLC40A1 Q9NP59 1/20 0.39
GRM5 P41594 1/20 0.38
MAP4K4 O95819 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3288158 0.80 CKS1B (0.45) CKS1BSKP2P2RY1RAB9ACLK4
SCHEMBL6136879 0.77 AR (0.49) CKS1BSKP2RAB9ACLK4
SCHEMBL1307835 0.77 MAP4K4 (0.47) CKS1BSKP2P2RY1RAB9ACLK4
SCHEMBL6136767 0.77 CLK4 (0.44) CKS1BSKP2P2RY1RAB9ACLK4
SCHEMBL12111333 0.76 P2RY1 (0.43) CKS1BSKP2EPAS1P2RY1RAB9A
SCHEMBL5362007 0.75 HCRTR1 (0.49) P2RY1HAO1
SCHEMBL10834101 0.75 NPSR1 (0.41) P2RY1
SCHEMBL1308224 0.74 MEN1 (0.58) CKS1BSKP2P2RY1RAB9A
SCHEMBL6579096 0.74 ALDH1A1 (0.50) GRM5
SCHEMBL3510232 0.74 PGR (0.52) CKS1BSKP2EPAS1VEGFAHAO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0072529-A1 Sulfur-substituted phenoxypyridines having antiviral activity THE DOW CHEMICAL COMPANY (US) 1983-02-23 EP disclosed