Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.49 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.49 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.49 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | QDPR | P09417 | 2/20 | 0.47 |
| ▸ | IGF1R | P08069 | 2/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11198460 | 0.81 | DRD2 (0.49) | CHRM2CHRM4CHRM5ADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL11199175 | 0.80 | DRD2 (0.48) | CHRM2CHRM4CHRM5ADRA2AADRA2B | |
| SCHEMBL11196119 | 0.77 | IGF1R (0.49) | CHRM2CHRM4CHRM5ADRA2AADRA2B | |
| SCHEMBL2207458 | 0.77 | CHRM2 (0.51) | CHRM2CHRM4CHRM5ADRA2AADRA2B | |
| SCHEMBL14980754 | 0.77 | CHRM2 (0.51) | CHRM2CHRM4CHRM5ADRA2AADRA2B | |
| SCHEMBL2204492 | 0.74 | ALDH1A1 (0.46) | CHRM2CHRM4CHRM5ADRA2AADRA2B | |
| SCHEMBL2205877 | 0.74 | CHRM2 (0.46) | CHRM2CHRM4CHRM5ADRA2AADRA2B | |
| SCHEMBL11198743 | 0.73 | DRD2 (0.52) | CHRM2CHRM4CHRM5ADRA2AADRA2B | |
| SCHEMBL11260900 | 0.72 | DRD2 (0.50) | CHRM2CHRM4CHRM5ADRA2AADRA2B | |
| SCHEMBL2207405 | 0.72 | CHRM2 (0.47) | CHRM2CHRM4CHRM5ADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4382942-A | ANTIEMETICS, PARKINSON*S DISEASE | ROUSSEL UCLAF (FR) | 1983-05-10 | — | — | US | disclosed |