Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | TYR | P14679 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6050836 | 0.77 | ALOX5 (0.37) | ALOX5CYP3A4TYRMEN1TP53 | |
| SCHEMBL10573937 | 0.77 | ALOX5 (0.37) | ALOX5CYP3A4TYRMEN1TP53 | |
| SCHEMBL6050776 | 0.74 | TYR (0.39) | ALOX5CYP3A4TYRMEN1TP53 | |
| SCHEMBL6050795 | 0.74 | ALOX5 (0.42) | ALOX5CYP3A4TYRMEN1TP53 | |
| SCHEMBL11000048 | 0.72 | ALDH1A1 (0.35) | ALOX5CYP3A4TYRMEN1TP53 | |
| SCHEMBL27760799 | 0.72 | GPR35 (0.57) | ALOX5CYP3A4TYRMEN1TP53 | |
| SCHEMBL26603205 | 0.72 | HIF1A (0.38) | ALOX5CYP3A4TYRMEN1TP53 | |
| SCHEMBL7995347 | 0.71 | TYR (0.36) | ALOX5CYP3A4TYRMEN1TP53 | |
| SCHEMBL1855556 | 0.70 | GPR35 (0.43) | ALOX5CYP3A4TYRMEN1TP53 | |
| SCHEMBL17449658 | 0.70 | ALOX5 (0.39) | ALOX5CYP3A4TYRMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4381311-A | Antiinflammatory 4,5-diaryl-α-(polyhalomethyl)-2-thiophenemethanols | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-04-26 | — | — | US | disclosed |
| EP-0055470-A1 | Antiinflammatory 4,5-diaryl-alpha-(polyhalomethyl)-2-thiophenemethanols | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-07-07 | — | — | EP | disclosed |