Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.44 |
| ▸ | CCKBR | P32239 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15383209 | 0.85 | MAPT (0.57) | SMN1; SMN2ALDH1A1GAATDP1MAPT | |
| SCHEMBL1120589 | 0.82 | GAA (0.59) | SMN1; SMN2ALDH1A1GAATDP1MAPT | |
| SCHEMBL28007796 | 0.79 | CYP1A2 (0.44) | SMN1; SMN2ALDH1A1MAPTKDM4ETOP2A | |
| SCHEMBL658049 | 0.79 | MAPT (0.59) | SMN1; SMN2ALDH1A1GAATDP1MAPT | |
| SCHEMBL1120542 | 0.79 | GAA (0.54) | SMN1; SMN2ALDH1A1GAATDP1MAPT | |
| SCHEMBL11953341 | 0.77 | KDM4E (0.58) | SMN1; SMN2ALDH1A1TDP1MAPTKDM4E | |
| SCHEMBL15741880 | 0.76 | ALDH1A1 (0.74) | ALDH1A1L3MBTL1CCKBRLMNA | |
| SCHEMBL4467166 | 0.74 | CYP4F2 (0.58) | SMN1; SMN2ALDH1A1GAATDP1MAPT | |
| SCHEMBL2743413 | 0.73 | KMT2A (0.54) | SMN1; SMN2ALDH1A1MAPTL3MBTL1HTT | |
| SCHEMBL17590526 | 0.73 | CYP4Z1 (0.59) | ALDH1A1GAATDP1MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280968-A2 | PYRIDO [3, 4-B]INDOLES AND METHODS OF USE | Medivation Technologies, Inc. (US) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009120717-A2 | PYRIDO [3, 4-B] INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2009-10-01 | — | — | WO | disclosed |