Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1120545 | 0.87 | GAA (0.57) | GAASMN1; SMN2ALDH1A1TDP1HTT | |
| SCHEMBL27558574 | 0.84 | KMT2A (0.54) | GAASMN1; SMN2ALDH1A1TDP1HTT | |
| SCHEMBL657243 | 0.83 | KDM4E (0.64) | GAASMN1; SMN2ALDH1A1TDP1HTT | |
| Hydrochloric Acid SCHEMBL11536222 | 0.82 | MAPT (0.65) | GAASMN1; SMN2ALDH1A1TDP1HTT | |
| SCHEMBL1120688 | 0.82 | MAPT (0.59) | GAASMN1; SMN2ALDH1A1HTTKDM4E | |
| SCHEMBL1120410 | 0.82 | SMN1; SMN2 (0.54) | GAASMN1; SMN2ALDH1A1TDP1HTT | |
| SCHEMBL5411982 | 0.77 | POLB (0.62) | GAASMN1; SMN2ALDH1A1TDP1HTT | |
| SCHEMBL1503956 | 0.75 | TSHR (0.69) | GAASMN1; SMN2ALDH1A1TDP1MAPT | |
| SCHEMBL1120518 | 0.75 | GAA (0.53) | GAASMN1; SMN2ALDH1A1HTTMAPT | |
| SCHEMBL10898232 | 0.74 | MEN1 (0.72) | GAASMN1; SMN2ALDH1A1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104395312-B | The Spirocyclic derivatives of 4,5-dihydro-pyrazolo [3,4-c] pyridin-2-ones, its preparation method and application | SICHUAN HAISCO PHARMACEUTICAL CO.,LTD. (CN) | 2016-04-27 | — | — | CN | disclosed |
| EP-2280968-A2 | PYRIDO [3, 4-B]INDOLES AND METHODS OF USE | Medivation Technologies, Inc. (US) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009120717-A2 | PYRIDO [3, 4-B] INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2009-10-01 | — | — | WO | disclosed |