Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 8/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11201763 | 0.84 | MTNR1A (0.45) | ADRB2ADRB1MTNR1AMEN1KMT2A | |
| SCHEMBL11476015 | 0.82 | MTNR1A (0.49) | ADRB2ADRB1MTNR1AADRB3ALDH1A1 | |
| SCHEMBL11570223 | 0.79 | MEN1 (0.64) | ADRB2ADRB1ADRB3MEN1ALDH1A1 | |
| SCHEMBL11476025 | 0.77 | MTNR1A (0.48) | ADRB2ADRB1MTNR1AADRB3MEN1 | |
| SCHEMBL7518458 | 0.77 | MTNR1A (0.69) | MTNR1AALDH1A1 | |
| SCHEMBL11478876 | 0.77 | MTNR1A (0.48) | ADRB2ADRB1MTNR1AADRB3ALDH1A1 | |
| SCHEMBL11478895 | 0.74 | MTNR1A (0.50) | ADRB2ADRB1MTNR1AADRB3ABCB1 | |
| SCHEMBL11266560 | 0.70 | TACR1 (0.39) | MTNR1AALDH1A1 | |
| SCHEMBL13533389 | 0.68 | MTNR1A (0.53) | MTNR1A | |
| SCHEMBL11652084 | 0.68 | ADRB3 (0.54) | ADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4387099-A | Alkanolamine derivatives | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1983-06-07 | — | — | US | disclosed |
| US-4327113-A | DRUGS FOR TREATMENT OF HEART DISEASES, ADRENERGIC BLOCKING AGENTS, ETC | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1982-04-27 | — | — | US | disclosed |
| US-4260632-A | ADRENERGIC BLOCKING AGENTS, CARDIOVASCULAR DISORDERS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-04-07 | — | — | US | disclosed |
| US-4221807-A | ADRENERGIC BLOCKING AGENTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-09-09 | — | — | US | disclosed |
| US-4141987-A | HYPOTENSIVE, ADRENERGIC BLOCKING AGENT | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1979-02-27 | — | — | US | disclosed |