Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 4/20 | 0.62 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.62 |
| ▸ | NT5E | P21589 | 2/20 | 0.62 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.56 |
| ▸ | NSD2 | O96028 | 4/20 | 0.50 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.50 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.50 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11440915 | 0.92 | CASP6 (0.73) | CASP6CTDSP1NT5EENPP2NSD2 | |
| SCHEMBL11435460 | 0.91 | CASP6 (0.54) | CASP6CTDSP1NT5EENPP2NSD2 | |
| SCHEMBL11208054 | 0.91 | CASP6 (0.62) | CASP6CTDSP1NT5EENPP2NSD2 | |
| SCHEMBL10905493 | 0.87 | NT5E (0.59) | CASP6CTDSP1NT5EENPP2NSD2 | |
| SCHEMBL11339168 | 0.86 | NT5E (0.58) | CASP6CTDSP1NT5EENPP2NSD2 | |
| SCHEMBL11433774 | 0.86 | CASP6 (0.64) | CASP6CTDSP1NT5EENPP2NSD2 | |
| SCHEMBL7897823 | 0.85 | CASP6 (0.65) | CASP6CTDSP1NT5EENPP2NSD2 | |
| SCHEMBL6017879 | 0.85 | CASP6 (0.84) | CASP6CTDSP1NT5EENPP2NSD2 | |
| SCHEMBL11435442 | 0.83 | CASP6 (0.49) | CASP6CTDSP1NT5EENPP2NSD2 | |
| SCHEMBL11426163 | 0.83 | CASP6 (0.73) | CASP6CTDSP1NT5EENPP2NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0013784-B1 | C-SUBSTITUTED NAPHTHALENEMONOSULFONIC UREIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMERICAN CYANAMID COMPANY (US) | 1983-02-23 | — | — | EP | disclosed |
| US-4297372-A | ANTIARTHRITIC AGENTS; COLLAGENASE AND PROTEOLYTIC ENZYME INHIBITORS; BONE, SKIN, AND ORAL DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1981-10-27 | — | — | US | disclosed |
| EP-0013784-A1 | C-Substituted naphthalenemonosulfonic ureides, process for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |
| US-4216165-A | Amine precursors to ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |
| US-4216164-A | Ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |
| US-4216166-A | Nitro precursors to amine precursors to ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |