SCHEMBL11205006

SCHEMBL11205006

CC(C)(C)c1ccc(OC(=O)c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2-c2ccccc2)c(C(C)(C)C)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APEX1 P27695 1/20 0.46
MAPT P10636 3/20 0.37
NPSR1 Q6W5P4 2/20 0.37
ALOX5 P09917 2/20 0.36
PTGS2 P35354 2/20 0.36
TDP1 Q9NUW8 2/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
CYP2C19 P33261 2/20 0.34
RXRA P19793 1/20 0.34
RXRB P28702 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
TSHR P16473 1/20 0.34
TNFRSF1A P19438 1/20 0.34
POLB P06746 1/20 0.34
PTPN5 P54829 1/20 0.34
ATM Q13315 1/20 0.33
AKR1C2 P52895 1/20 0.32
AKR1C1 Q04828 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL995615 0.85 APEX1 (0.46) APEX1MAPTNPSR1ALOX5PTGS2
SCHEMBL501948 0.82 APEX1 (0.45) APEX1MAPTNPSR1ALOX5PTGS2
SCHEMBL28994580 0.80 MAPT (0.43) APEX1MAPTNPSR1ALOX5PTGS2
SCHEMBL30366235 0.80 MAPT (0.43) APEX1MAPTNPSR1ALOX5PTGS2
SCHEMBL27604163 0.80 ALDH1A1 (0.41) MAPTALOX5PTGS2TNFRSF1APOLB
SCHEMBL23668727 0.79 APEX1 (0.44) APEX1MAPTNPSR1ALOX5PTGS2
SCHEMBL30197305 0.79 APEX1 (0.44) APEX1MAPTNPSR1ALOX5PTGS2
SCHEMBL450851 0.78 APEX1 (0.49) APEX1MAPTNPSR1ALOX5PTGS2
SCHEMBL30931410 0.78 APEX1 (0.38) APEX1MAPTNPSR1ALOX5PTGS2
SCHEMBL30272446 0.78 GLRA3 (0.45) NPSR1L3MBTL1TNFRSF1AAKR1C2AKR1C1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0094048-A2 Poly(piperidylamine)alkanes and synthetic resin compositions stabilized thereby ADEKA ARGUS CHEMICAL CO., Ltd. (JP) 1983-11-16 EP disclosed