Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PPID | Q08752 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27558574 | 0.87 | KMT2A (0.54) | GAASMN1; SMN2HTTDHODHPOLB | |
| SCHEMBL1120589 | 0.87 | GAA (0.59) | GAASMN1; SMN2HTTPOLBMAPT | |
| SCHEMBL1120402 | 0.86 | MEN1 (0.48) | GAASMN1; SMN2HTTPOLBRAB9A | |
| SCHEMBL1120542 | 0.83 | GAA (0.54) | GAASMN1; SMN2HTTHSD17B10DHODH | |
| SCHEMBL4035087 | 0.82 | POLB (0.65) | GAASMN1; SMN2HTTHSD17B10DHODH | |
| SCHEMBL1120518 | 0.81 | GAA (0.53) | GAASMN1; SMN2HTTHSD17B10RAB9A | |
| Water SCHEMBL9248793 | 0.81 | POLB (0.63) | GAASMN1; SMN2HTTHSD17B10DHODH | |
| Malonic Acid Diethyl Ester SCHEMBL8399632 | 0.77 | GAA (0.71) | GAASMN1; SMN2HTTHSD17B10DHODH | |
| SCHEMBL10192183 | 0.77 | PPID (0.62) | GAASMN1; SMN2HTTHSD17B10POLB | |
| SCHEMBL1120580 | 0.75 | ALDH1A1 (0.48) | SMN1; SMN2POLBRAB9AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280968-A2 | PYRIDO [3, 4-B]INDOLES AND METHODS OF USE | Medivation Technologies, Inc. (US) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009120717-A2 | PYRIDO [3, 4-B] INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2009-10-01 | — | — | WO | disclosed |