Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.57 |
| ▸ | DRD3 | P35462 | 13/20 | 0.57 |
| ▸ | HTR1A | P08908 | 3/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11203478 | 0.90 | HTR1A (0.55) | DRD2DRD3HTR1AFYNDRD4 | |
| Sulfuric Acid SCHEMBL11209713 | 0.80 | DRD2 (0.46) | DRD2DRD3HTR1AFYNDRD4 | |
| SCHEMBL11209001 | 0.80 | DRD2 (0.45) | DRD2DRD3HTR1ADRD4DRD1 | |
| Hydrochloric Acid SCHEMBL11207856 | 0.79 | DRD2 (0.46) | DRD2DRD3HTR1ADRD4 | |
| Cadaverine Tartrate SCHEMBL11212859 | 0.79 | HTR1D (0.45) | DRD2DRD3HTR1AFYNDRD4 | |
| Hydrochloric Acid SCHEMBL11206341 | 0.78 | DRD2 (0.44) | DRD2DRD3HTR1ADRD4DRD1 | |
| SCHEMBL11267287 | 0.75 | HTR1A (0.64) | DRD2DRD3HTR1AFYNDRD4 | |
| SCHEMBL12510926 | 0.73 | NOS3 (0.37) | — | |
| SCHEMBL10760766 | 0.72 | DRD2 (0.63) | DRD2DRD3HTR1AFYNDRD4 | |
| SCHEMBL10758705 | 0.72 | DRD3 (0.60) | DRD2DRD3HTR1AFYNDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0013789-B1 | AMINO-SUBSTITUTED 4,5,6,7-TETRAHYDRO-1H (OR 2H)-INDAZOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELI LILLY AND COMPANY (US) | 1983-02-02 | — | — | EP | claimed |
| US-4276300-A | PROLACTIN INHIBITORS | ELI LILLY AND COMPANY (US) | 1981-06-30 | — | — | US | claimed |
| EP-0013789-A1 | Amino-substituted 4,5,6,7-tetrahydro-1H (or 2H)-indazoles, their preparation and pharmaceutical compositions containing them | ELI LILLY AND COMPANY (US) | 1980-08-06 | — | — | EP | claimed |
| EP-0013789-B1 | AMINO-SUBSTITUTED 4,5,6,7-TETRAHYDRO-1H (OR 2H)-INDAZOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELI LILLY AND COMPANY (US) | 1983-02-02 | — | — | EP | disclosed |
| EP-0013789-A1 | Amino-substituted 4,5,6,7-tetrahydro-1H (or 2H)-indazoles, their preparation and pharmaceutical compositions containing them | ELI LILLY AND COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |