Orthotolidine

Orthotolidine

SCHEMBL11207214

Cc1c(N)cccc1N.Cc1cc(-c2ccc(N)c(C)c2)ccc1N.Cc1cc(N)cc(N)c1.Cc1ccc(N)c(N)c1.Cc1ccc(N)cc1N.Cc1cccc(N)c1N

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.38
CYP3A4 P08684 3/20 0.38
ALDH1A1 P00352 2/20 0.38
TSHR P16473 2/20 0.38
CD44 P16070 1/20 0.38
CASP1 P29466 1/20 0.38
TP53 P04637 1/20 0.36
THRB P10828 1/20 0.36
ALOX15 P16050 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
PIK3CA P42336 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15011 0.93 ALDH1A1 (0.44) TDP1CYP3A4ALDH1A1TSHRCD44
2,5-Xylidine SCHEMBL28278837 0.78 ALDH1A1 (0.49) TDP1CYP3A4ALDH1A1TSHRCD44
2,5-Xylidine SCHEMBL33981 0.76 ALDH1A1 (0.46) TDP1CYP3A4ALDH1A1TSHRCD44
SCHEMBL9173074 0.74 CASP1 (0.68) TDP1CYP3A4ALDH1A1TSHRCD44
SCHEMBL29102567 0.74 CD44 (0.68) TDP1CYP3A4ALDH1A1TSHRCD44
2,5-Xylidine SCHEMBL28081135 0.73 ALDH1A1 (0.35) TDP1ALDH1A1CD44CASP1
SCHEMBL6026377 0.73 ALDH1A1 (0.71) TDP1CYP3A4ALDH1A1TSHRCASP1
SCHEMBL6156968 0.71 CASP1 (0.74) TDP1CYP3A4ALDH1A1TSHRCD44
2,5-Xylidine SCHEMBL11124717 0.70 TDP1 (0.77) TDP1CYP3A4ALDH1A1TSHRCD44
2,5-Xylidine SCHEMBL9751765 0.69 ALDH1A1 (0.63) TDP1CYP3A4ALDH1A1TSHRCD44

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4389510-A Water soluble polyimide prepared from 1,2,3,4 butane tetracarboxylic acid and method of preparation UNITED TECHNOLOGIES CORPORATION (US) 1983-06-21 US disclosed