Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.46 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4461255 | 0.88 | GCGR (0.58) | POLBALDH1A1MAPTMEN1IDO1 | |
| SCHEMBL11733046 | 0.79 | TRPV1 (0.43) | POLBALDH1A1MAPTMEN1IDO1 | |
| SCHEMBL28485599 | 0.75 | POLB (0.73) | POLBALDH1A1MAPTMEN1IDO1 | |
| SCHEMBL11736748 | 0.75 | SIRT1 (0.43) | POLBALDH1A1RAB9AHPGDTSHR | |
| SCHEMBL7092828 | 0.75 | ALDH1A1 (0.55) | ALDH1A1MAPTMEN1KMT2AHPGD | |
| SCHEMBL7093919 | 0.75 | ALDH1A1 (0.55) | ALDH1A1MAPTMEN1KMT2AHPGD | |
| SCHEMBL11193218 | 0.75 | IDO1 (0.50) | POLBALDH1A1MAPTMEN1IDO1 | |
| SCHEMBL11180564 | 0.75 | ALDH1A1 (0.50) | POLBALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7089988 | 0.74 | POLB (0.55) | POLBALDH1A1MAPTMEN1RAB9A | |
| SCHEMBL7038229 | 0.74 | ALDH1A1 (0.56) | ALDH1A1MAPTMEN1IDO1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0010361-B1 | BIS-IMIDAZOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1983-04-27 | — | — | EP | disclosed |
| EP-0010361-A1 | Bis-imidazoles, their preparation and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1980-04-30 | — | — | EP | disclosed |
| US-4188397-A | ANTIARTHRITIC, ANTIINFLAMMATORY | SMITHKLINE CORPORATION (US) | 1980-02-12 | — | — | US | disclosed |