Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 15/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10751448 | 0.79 | TBXAS1 (1.00) | TBXAS1MEN1LMNAKMT2AGAA | |
| SCHEMBL10749397 | 0.78 | TBXAS1 (1.00) | TBXAS1MEN1LMNAKMT2AGAA | |
| SCHEMBL10750647 | 0.78 | TBXAS1 (1.00) | TBXAS1MEN1LMNAKMT2AGAA | |
| SCHEMBL11405859 | 0.77 | NPC1 (0.49) | MEN1LMNAKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL10749342 | 0.77 | TBXAS1 (0.72) | TBXAS1MEN1LMNAKMT2AGAA | |
| Dazoxiben SCHEMBL11554 | 0.76 | TBXAS1 (1.00) | TBXAS1MEN1LMNAKMT2AKDM4E | |
| SCHEMBL10750806 | 0.76 | TBXAS1 (0.63) | TBXAS1MEN1LMNAKMT2AMAPK1 | |
| SCHEMBL8690701 | 0.76 | TBXAS1 (0.75) | TBXAS1MEN1LMNAKMT2AMAPK1 | |
| SCHEMBL10748630 | 0.76 | TBXAS1 (0.74) | TBXAS1MEN1LMNAKMT2AGAA | |
| SCHEMBL8690308 | 0.75 | TBXAS1 (0.78) | TBXAS1MEN1LMNAKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0035863-B1 | IMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | Pfizer Limited (GB) | 1983-10-26 | — | — | EP | claimed |
| US-4350696-A | INHIBITORS OF THROMBOXANE SYNTHETASE ENZYME | PFIZER INC. (US) | 1982-09-21 | — | — | US | claimed |
| EP-0035863-B1 | IMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | Pfizer Limited (GB) | 1983-10-26 | — | — | EP | disclosed |