SCHEMBL11208690

SCHEMBL11208690

C=CCOCCOC(=O)C(C#N)=C(c1ccccc1)c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.47
LMNA P02545 2/20 0.47
MAPK1 P28482 2/20 0.47
CYP3A4 P08684 1/20 0.37
MAPT P10636 2/20 0.34
THRB P10828 1/20 0.34
XBP1 P17861 1/20 0.34
RAB9A P51151 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
SMN1; SMN2 Q16637 3/20 0.33
TSHR P16473 1/20 0.33
HSD17B10 Q99714 1/20 0.33
PTP4A3 O75365 1/20 0.33
PTP4A1 Q93096 1/20 0.33
PKM P14618 1/20 0.33
ESR1 P03372 1/20 0.33
DNM1 Q05193 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11398678 0.90 ALDH1A1 (0.47) ALDH1A1LMNAMAPK1CYP3A4MAPT
SCHEMBL521197 0.88 ALDH1A1 (0.52) ALDH1A1LMNAMAPK1CYP3A4MAPT
SCHEMBL11421380 0.87 ALDH1A1 (0.47) ALDH1A1LMNAMAPK1MAPTTHRB
SCHEMBL24703978 0.85 ALDH1A1 (0.50) ALDH1A1LMNAMAPK1MAPTTHRB
SCHEMBL11405314 0.85 LMNA (0.48) ALDH1A1LMNAMAPK1MAPTXBP1
SCHEMBL9248195 0.84 THRB (0.51) ALDH1A1LMNAMAPK1CYP3A4MAPT
SCHEMBL11497916 0.84 ALDH1A1 (0.41) ALDH1A1LMNAMAPK1CYP3A4
SCHEMBL11394678 0.83 ALDH1A1 (0.49) ALDH1A1LMNAMAPK1MAPTTHRB
SCHEMBL16486985 0.83 ALDH1A1 (0.56) ALDH1A1LMNAMAPK1MAPTTHRB
SCHEMBL12253191 0.82 ALDH1A1 (0.58) ALDH1A1LMNAMAPK1MAPTXBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4263366-A Radiation curable coating composition comprising an oligomer and a copolymerizable ultra-violet absorber GAF CORPORATION (US) 1981-04-21 US claimed
US-4202834-A Copolymerizable, ultraviolet light absorber (2-cyano-3,3-diphenylacryloxy) alkylene ethylenic ethers GAF CORPORATION (US) 1980-05-13 US claimed
WO-2022255228-A1 COMPOSITION, CURED PRODUCT OR COMPACT, OPTICAL MEMBER, AND LENS 富士フイルム株式会社 2022-12-08 WO disclosed
EP-0026339-B1 RADIATION CURABLE COATING COMPOSITION AND PROCESS FOR COATING A SUBSTRATE THEREWITH GAF CORPORATION (US) 1983-11-30 EP disclosed
US-4263366-A Radiation curable coating composition comprising an oligomer and a copolymerizable ultra-violet absorber GAF CORPORATION (US) 1981-04-21 US disclosed
EP-0026339-A1 Radiation curable coating composition and process for coating a substrate therewith GAF CORPORATION (US) 1981-04-08 EP disclosed
EP-0017703-A1 Copolymerizable (2-cyano-3,3-diarylacryloxy)alkylene compounds, a method of making them and the use of these compounds as ultraviolet light absorbers GAF CORPORATION (US) 1980-10-29 EP disclosed
US-4202834-A Copolymerizable, ultraviolet light absorber (2-cyano-3,3-diphenylacryloxy) alkylene ethylenic ethers GAF CORPORATION (US) 1980-05-13 US disclosed