Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4457 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL360707 | 0.79 | — | — | |
| Fluoride SCHEMBL27615783 | 0.79 | — | — | |
| Ammonia Solution, Strong SCHEMBL15169416 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL5960465 | 0.79 | — | — | |
| Phosphine SCHEMBL28646269 | 0.79 | — | — | |
| Water SCHEMBL6720123 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL5960464 | 0.79 | HSP90AA1 (0.35) | — | |
| Boric Acid SCHEMBL8843849 | 0.77 | HSP90AA1 (0.31) | — | |
| Benzene SCHEMBL28241501 | 0.77 | NOS2 (0.35) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4402907-A | Triazine carboxylic acids as corrosion inhibitors for aqueous systems | CIBA-GEIGY CORPORATION (US) | 1983-09-06 | — | — | US | disclosed |