Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3829775 | 0.80 | CYP2C19 (0.55) | HIF1ACCR3NPSR1ACHEPPARG | |
| SCHEMBL18255541 | 0.80 | HIF1A (0.53) | HIF1ACCR3NPSR1ACHEKDM4E | |
| SCHEMBL3834366 | 0.80 | HIF1A (0.50) | HIF1ACCR3ACHEKDM4EPPARG | |
| SCHEMBL18252783 | 0.78 | HIF1A (0.51) | HIF1ACCR3NPSR1ACHEKDM4E | |
| SCHEMBL27983247 | 0.73 | CCR3 (0.54) | HIF1ACCR3ACHEKDM4EPPARG | |
| SCHEMBL27983483 | 0.73 | CCR3 (0.54) | HIF1ACCR3ACHEKDM4EPPARG | |
| SCHEMBL28644365 | 0.73 | ACHE (0.46) | HIF1ACCR3ACHEPPARGPPARD | |
| SCHEMBL31376296 | 0.71 | PPARG (0.53) | HIF1ACCR3NPSR1ACHEKDM4E | |
| SCHEMBL14032381 | 0.71 | PPARG (0.49) | HIF1ACCR3NPSR1ACHEKDM4E | |
| SCHEMBL27983181 | 0.71 | PPARG (0.53) | HIF1ACCR3NPSR1ACHEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0036773-B1 | 2,3-DIHYDROBENZOFURANS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1983-02-16 | — | — | EP | disclosed |
| EP-0036773-A1 | 2,3-Dihydrobenzofurans, process for their preparation and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1981-09-30 | — | — | EP | disclosed |
| US-4254140-A | USED FOR CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENT | SMITHKLINE CORPORATION (US) | 1981-03-03 | — | — | US | disclosed |