Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 13/20 | 0.44 |
| ▸ | BCHE | P06276 | 10/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1733144 | 0.84 | ACHE (0.61) | ACHEBCHETDP1PRMT6 | |
| SCHEMBL11479635 | 0.84 | ACHE (0.45) | ACHEBCHEALDH1A1TDP1TSHR | |
| Hydrochloric Acid SCHEMBL3081249 | 0.83 | ACHE (0.59) | ACHEBCHEPRMT6 | |
| SCHEMBL11409042 | 0.79 | ALDH1A1 (0.45) | ACHEBCHEALDH1A1TDP1TSHR | |
| SCHEMBL11359610 | 0.79 | ACHE (0.41) | ACHEBCHEALDH1A1TDP1TSHR | |
| SCHEMBL183551 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL11410866 | 0.77 | ALDH1A1 (0.43) | ACHEBCHEALDH1A1TDP1TSHR | |
| SCHEMBL7400838 | 0.77 | ALDH1A1 (0.47) | ACHEALDH1A1TDP1TSHRKDM4E | |
| SCHEMBL10960920 | 0.74 | PYCR1 (0.47) | ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL11370388 | 0.72 | ALDH1A1 (0.44) | ACHEBCHEALDH1A1TDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002930-B1 | AMINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1983-12-14 | — | — | EP | disclosed |
| US-4304780-A | Aminoalkylthiophene derivatives as histamine H2 -antagonists | GLAXO GROUP LIMITED (GB) | 1981-12-08 | — | — | US | disclosed |
| US-4279911-A | ANTIHISTAMINES | GLAXO GROUP LIMITED (GB) | 1981-07-21 | — | — | US | disclosed |
| US-4233302-A | ANTIHISTAMINES, ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1980-11-11 | — | — | US | disclosed |
| EP-0002930-A1 | Amine derivatives, their preparation and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1979-07-11 | — | — | EP | disclosed |