Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.41 |
| ▸ | ESR1 | P03372 | 6/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22568983 | 0.89 | CYP11B1 (0.45) | PTGS2CYP11B1CYP11B2ESR2ESR1 | |
| SCHEMBL3651332 | 0.89 | MAOA (0.43) | PTGS2CYP11B1CYP11B2ESR2ESR1 | |
| SCHEMBL5694168 | 0.85 | ESR2 (0.48) | PTGS2CYP11B1CYP11B2ESR2 | |
| SCHEMBL11036322 | 0.85 | CYP11B1 (0.54) | PTGS2CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL30957747 | 0.85 | ESR2 (0.45) | CYP11B1CYP11B2ESR2ESR1HSD17B1 | |
| SCHEMBL30957748 | 0.85 | ESR2 (0.45) | CYP11B1CYP11B2ESR2ESR1HSD17B1 | |
| SCHEMBL11209313 | 0.81 | CYP11B1 (0.56) | PTGS2CYP11B1CYP11B2ESR2ESR1 | |
| SCHEMBL5694157 | 0.81 | CA12 (0.50) | PTGS2CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL22569003 | 0.80 | ESR1 (0.42) | PTGS2CYP11B1CYP11B2ESR2ESR1 | |
| SCHEMBL22568911 | 0.80 | KIF11 (0.46) | PTGS2CYP11B1CYP11B2ESR2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4400543-A | ANTIFERTILITY AGENTS | ELI LILLY AND COMPANY (US) | 1983-08-23 | — | — | US | disclosed |
| US-4323707-A | USEFUL FOR AMIMALS, AROYL-PHENYL-NAPHTHALENES OR DIHYDRONAPHTHALENES | ELI LILLY AND COMPANY (US) | 1982-04-06 | — | — | US | disclosed |
| US-4230862-A | 3-PHENYL-4-AROYL-1,2-DIHYDRONAPHTHALENES AND 1-ARYOYL-2-PHENYLNAPHTHALENES | ELI LILLY AND COMPANY (US) | 1980-10-28 | — | — | US | disclosed |