Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.56 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | QDPR | P09417 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22568909 | 0.89 | CYP11B1 (0.45) | CYP11B1CYP11B2CYP19A1NISCHPTGS2 | |
| SCHEMBL28114823 | 0.85 | CYP11B1 (0.53) | CYP11B1CYP11B2CYP19A1NISCHPTGS2 | |
| SCHEMBL29683776 | 0.84 | CYP11B2 (0.68) | CYP11B1CYP11B2CYP19A1NISCHPTGS2 | |
| SCHEMBL5607604 | 0.84 | CYP11B2 (0.68) | CYP11B1CYP11B2CYP19A1NISCHPTGS2 | |
| SCHEMBL5607529 | 0.82 | CYP11B2 (0.57) | CYP11B1CYP11B2CYP19A1NISCHPTGS2 | |
| SCHEMBL11211277 | 0.81 | PTGS2 (0.45) | CYP11B1CYP11B2CYP19A1PTGS2ESR2 | |
| SCHEMBL10402898 | 0.81 | CYP11B1 (0.56) | CYP11B1CYP11B2CYP19A1NISCHPTGS2 | |
| SCHEMBL11466575 | 0.81 | CYP11B2 (0.56) | CYP11B1CYP11B2CYP19A1NISCHPTGS2 | |
| SCHEMBL30957747 | 0.81 | ESR2 (0.45) | CYP11B1CYP11B2CYP19A1ESR2ESR1 | |
| SCHEMBL30957748 | 0.81 | ESR2 (0.45) | CYP11B1CYP11B2CYP19A1ESR2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4400543-A | ANTIFERTILITY AGENTS | ELI LILLY AND COMPANY (US) | 1983-08-23 | — | — | US | disclosed |
| US-4323707-A | USEFUL FOR AMIMALS, AROYL-PHENYL-NAPHTHALENES OR DIHYDRONAPHTHALENES | ELI LILLY AND COMPANY (US) | 1982-04-06 | — | — | US | disclosed |
| US-4230862-A | 3-PHENYL-4-AROYL-1,2-DIHYDRONAPHTHALENES AND 1-ARYOYL-2-PHENYLNAPHTHALENES | ELI LILLY AND COMPANY (US) | 1980-10-28 | — | — | US | disclosed |