Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.56 |
| ▸ | DRD3 | P35462 | 5/20 | 0.56 |
| ▸ | DRD4 | P21917 | 4/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | PRCP | P42785 | 1/20 | 0.56 |
| ▸ | EBP | Q15125 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 2/20 | 0.45 |
| ▸ | DRD5 | P21918 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11115019 | 0.99 | DRD2 (0.55) | DRD2DRD3DRD4SIGMAR1NFKB1 | |
| Hydrochloric Acid SCHEMBL11117789 | 0.84 | DRD2 (0.58) | DRD2DRD3DRD4DRD1DRD5 | |
| Bromide SCHEMBL11116998 | 0.80 | DRD3 (0.55) | DRD2DRD3DRD4SIGMAR1NFKB1 | |
| Bromide SCHEMBL11116377 | 0.77 | DRD3 (0.53) | DRD2DRD3DRD4SIGMAR1NFKB1 | |
| Bromide SCHEMBL11116380 | 0.77 | DRD3 (0.53) | DRD2DRD3DRD4SIGMAR1NFKB1 | |
| Bromide SCHEMBL11117059 | 0.77 | SIGMAR1 (0.55) | DRD2DRD3DRD4SIGMAR1NFKB1 | |
| SCHEMBL17294786 | 0.76 | DRD2 (0.73) | DRD2DRD3DRD4SIGMAR1NFKB1 | |
| SCHEMBL1751922 | 0.75 | ALDH1A1 (0.57) | — | |
| Bromide SCHEMBL11117061 | 0.74 | DRD3 (0.54) | DRD2DRD3DRD4SIGMAR1NFKB1 | |
| SCHEMBL11116728 | 0.73 | DRD3 (0.56) | DRD2DRD3DRD4SIGMAR1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0077607-A1 | N-substituted 3-aryl piperidines and derivatives thereof | BEECHAM GROUP PLC (GB) | 1983-04-27 | — | — | EP | disclosed |