Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30668163 | 0.89 | MAPT (0.54) | HTTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5073351 | 0.89 | MAPT (0.54) | HTTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL975946 | 0.86 | KDM4E (0.55) | HTTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1286684 | 0.84 | IRAK4 (0.53) | HTTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1655964 | 0.84 | IRAK4 (0.68) | HTTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL29930602 | 0.84 | ALDH1A1 (0.48) | HTTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2301384 | 0.84 | ALDH1A1 (0.48) | HTTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4654255 | 0.82 | DRD1 (0.48) | HTTALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL1856862 | 0.81 | SLC6A3 (0.56) | HTTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL22717478 | 0.81 | DRD1 (0.45) | HTTALDH1A1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-58008035-A | — | — | None | — | — | JP | disclosed |
| CN-105814060-B | Imidazo-triazine derivative as TNF active regulators | UCB生物制药私人有限公司 | 2018-02-13 | — | — | CN | disclosed |
| CN-105814061-B | Imidazopyridazine derivative as TNF active regulators | UCB生物制药私人有限公司 | 2018-01-26 | — | — | CN | disclosed |
| JP-S588035-A | DIFLUOROMETHOXYPHENYL KETONE DERIVATIVE AND ITS PREPARATION | NISSAN CHEM IND LTD | 1983-01-18 | — | — | JP | disclosed |