SCHEMBL1655964

SCHEMBL1655964

NC(=O)c1ccccc1OC(F)F

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IRAK4 Q9NWZ3 1/20 0.68
CTNNB1 P35222 1/20 0.55
HTT P42858 5/20 0.50
ALDH1A1 P00352 4/20 0.47
KDM4E B2RXH2 3/20 0.46
MAPT P10636 3/20 0.46
LMNA P02545 3/20 0.46
KMT2A Q03164 2/20 0.46
MEN1 O00255 1/20 0.46
NR1I2 O75469 1/20 0.46
CHRM2 P08172 1/20 0.46
CYP3A4 P08684 1/20 0.46
ADRA2A P08913 1/20 0.46
OPRK1 P41145 1/20 0.46
HTR2B P41595 1/20 0.46
SLC6A3 Q01959 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
PARP1 P09874 1/20 0.46
SMN1; SMN2 Q16637 4/20 0.46
NPC1 O15118 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7113007 0.85 IRAK4 (0.64) IRAK4CTNNB1HTTALDH1A1KDM4E
SCHEMBL11212937 0.84 HTT (0.49) IRAK4HTTALDH1A1KDM4EMAPT
SCHEMBL15270578 0.83 IRAK4 (0.49) IRAK4CTNNB1HTTALDH1A1KDM4E
SCHEMBL975946 0.82 KDM4E (0.55) HTTALDH1A1KDM4EMAPTLMNA
SCHEMBL2301384 0.81 ALDH1A1 (0.48) IRAK4HTTALDH1A1KDM4EMAPT
SCHEMBL29930602 0.81 ALDH1A1 (0.48) IRAK4HTTALDH1A1KDM4EMAPT
SCHEMBL1286684 0.81 IRAK4 (0.53) IRAK4HTTALDH1A1KDM4ELMNA
SCHEMBL2103513 0.81 IRAK4 (1.00) IRAK4CTNNB1HTTALDH1A1KDM4E
SCHEMBL29733167 0.81 IRAK4 (0.46) IRAK4CTNNB1HTTALDH1A1KMT2A
SCHEMBL22987538 0.80 CTSD (0.62) HTTALDH1A1KDM4EMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023110673-A1 PHOSPHODIESTERASES INHIBITORS TO PROMOTE IN VITRO PLANT CELL REPROGRAMMING TOWARDS PLANT EMBRYOGENESIS OR MICROCALLUS FORMATION CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) 2023-06-22 WO claimed
EP-1773768-B1 PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS EXELIXIS INC (US) 2018-08-22 EP claimed
CN-103304475-A Benzoic amide compound as well as preparation method and application thereof HUNAN QIANJIN XIANGJIANG PHARM CO LTD 2013-09-18 CN claimed
JP-2011512395-A 2011-04-21 JP claimed
EP-2262504-A1 COMBINATION THERAPY 238 AstraZeneca AB (SE) 2010-12-22 EP claimed
EP-2217234-A2 COMBINATIONS OF MEK INHIBITORS WITH MTOR INHIBITORS AstraZeneca AB (SE) 2010-08-18 EP claimed
EP-2197552-A2 NOVEL TETRAHYDROFUSEDPYRIDINES AS HISTONE DEACETYLASE INHIBITORS 4SC AG (DE) 2010-06-23 EP claimed
WO-2009104019-A1 COMBINATION THERAPY 238 ASTRAZENECA AB (SE) 2009-08-27 WO claimed
WO-2009050506-A2 COMBINATION 059 ASTRAZENECA AB (SE) 2009-04-23 WO claimed
WO-2009037001-A2 NOVEL TETRAHYDROFUSEDPYRIDINES AS HISTONE DEACETYLASE INHIBITORS 4SC AG (DE) 2009-03-26 WO claimed
EP-1773768-A4 PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS EXELIXIS INC (US) 2008-08-06 EP claimed
EP-1773768-A2 PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS Exelixis, Inc. (US) 2007-04-18 EP claimed
WO-2006012642-A2 PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS EXELIXIS, INC. (US) 2006-02-02 WO claimed
EP-1126833-A4 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES INC (US) 2004-09-08 EP claimed
EP-1150565-A1 THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF LION bioscience AG (DE) 2001-11-07 EP claimed
EP-1126833-A2 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES, INC. (US) 2001-08-29 EP claimed
WO-2000045635-A1 THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF LION BIOSCIENCE AG (DE) 2000-08-10 WO claimed
WO-2000025768-A1 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES, INC. (US) 2000-05-11 WO claimed
CN-119546341-A Proteolytic targeting chimeric (PROTAC) compositions using ubiquitin conjugated enzyme ligands 布普格生物制药公司 2025-02-28 CN disclosed
WO-2000045635-A1 THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF LION BIOSCIENCE AG (DE) 2000-08-10 WO disclosed