Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 6/20 | 0.63 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11207086 | 0.87 | TBXAS1 (0.67) | TBXAS1CYP19A1PKMCYP3A4CYP2D6 | |
| SCHEMBL27285135 | 0.81 | NPC1 (0.60) | TBXAS1CYP19A1NPC1RAB9ACYP3A4 | |
| SCHEMBL10947477 | 0.81 | TBXAS1 (0.72) | TBXAS1CYP19A1PKM | |
| SCHEMBL11208084 | 0.79 | TBXAS1 (0.62) | TBXAS1CYP19A1NPC1RAB9APKM | |
| SCHEMBL11206265 | 0.78 | TBXAS1 (0.61) | TBXAS1CYP19A1NPC1RAB9APKM | |
| SCHEMBL10852178 | 0.78 | TBXAS1 (1.00) | TBXAS1CYP19A1 | |
| SCHEMBL11354168 | 0.77 | TBXAS1 (0.74) | TBXAS1CYP19A1 | |
| SCHEMBL10945811 | 0.77 | TBXAS1 (0.78) | TBXAS1CYP19A1 | |
| Hydrochloric Acid SCHEMBL10854369 | 0.77 | TBXAS1 (1.00) | TBXAS1CYP19A1 | |
| Hydrochloric Acid SCHEMBL7014888 | 0.76 | GAA (0.69) | NPC1RAB9APKMTP53MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0035863-B1 | IMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | Pfizer Limited (GB) | 1983-10-26 | — | — | EP | claimed |
| US-4350696-A | INHIBITORS OF THROMBOXANE SYNTHETASE ENZYME | PFIZER INC. (US) | 1982-09-21 | — | — | US | claimed |
| EP-0035863-B1 | IMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | Pfizer Limited (GB) | 1983-10-26 | — | — | EP | disclosed |
| US-4350696-A | INHIBITORS OF THROMBOXANE SYNTHETASE ENZYME | PFIZER INC. (US) | 1982-09-21 | — | — | US | disclosed |
| EP-0035863-A1 | Imidazole derivatives, process for their preparation and pharmaceutical compositions thereof | Pfizer Limited (GB) | 1981-09-16 | — | — | EP | disclosed |