SCHEMBL11213465

SCHEMBL11213465

CC1Cc2c(CCN(C)C)ccc(O)c2O1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.45
MAOA P21397 4/20 0.40
HTR2A P28223 6/20 0.37
HTR2C P28335 4/20 0.36
HTR1A P08908 2/20 0.35
DRD2 P14416 2/20 0.34
HTR2B P41595 3/20 0.34
DRD1 P21728 2/20 0.34
DRD3 P35462 2/20 0.34
PARP1 P09874 1/20 0.34
HTR1D P28221 1/20 0.34
HTR1B P28222 1/20 0.34
HTR1E P28566 1/20 0.34
ADORA2A P29274 1/20 0.34
ADORA2B P29275 1/20 0.34
HTR7 P34969 1/20 0.34
HTR5A P47898 1/20 0.34
HTR6 P50406 1/20 0.34
DRD4 P21917 1/20 0.33
DRD5 P21918 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11210668 0.85 DRD2 (0.49) MAOBMAOAHTR2AHTR1ADRD2
Bromide SCHEMBL11211539 0.84 DRD2 (0.48) MAOBMAOAHTR2AHTR1ADRD2
SCHEMBL11205785 0.82 MAOB (0.47) MAOBMAOADRD2DRD1DRD3
Bromide SCHEMBL11207077 0.81 MAOB (0.46) MAOBMAOADRD2DRD1DRD3
SCHEMBL11213700 0.77 MAOB (0.42) MAOBMAOAPARP1KDM4EPOLB
Bromide SCHEMBL11209187 0.74 MAOB (0.45) MAOBMAOAPARP1KDM4EPOLB
SCHEMBL1285699 0.67 MAOA (0.51) MAOBMAOAHTR1ADRD2PARP1
SCHEMBL2367078 0.66 HTR2A (0.49) HTR2AHTR2CHTR1AHTR2BDRD1
SCHEMBL5544997 0.63 MAOA (0.62) MAOBMAOAHTR1ADRD2DRD3
SCHEMBL13520169 0.63 HPGD (0.43) MAOBMAOAHTR1ADRD2DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0036773-B1 2,3-DIHYDROBENZOFURANS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SMITHKLINE BECKMAN CORPORATION (US) 1983-02-16 EP disclosed
EP-0036773-A1 2,3-Dihydrobenzofurans, process for their preparation and pharmaceutical compositions containing them SMITHKLINE BECKMAN CORPORATION (US) 1981-09-30 EP disclosed
US-4254140-A USED FOR CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENT SMITHKLINE CORPORATION (US) 1981-03-03 US disclosed