Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.32 |
| ▸ | SOD1 | P00441 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18037119 | 0.83 | HPGD (0.41) | HPGDMEN1KMT2ACA1CA2 | |
| SCHEMBL4408434 | 0.83 | MEN1 (0.43) | HPGDMEN1KMT2ACA1CA2 | |
| SCHEMBL11236855 | 0.75 | HPGD (0.42) | HPGDMEN1KMT2ACA1CA2 | |
| SCHEMBL28283725 | 0.73 | CYP1A2 (0.41) | HPGDMEN1KMT2ACA1CA2 | |
| SCHEMBL15849787 | 0.70 | MEN1 (0.30) | MEN1KMT2A | |
| 1,4-Dichlorobenzene SCHEMBL27265166 | 0.69 | LMNA (0.57) | CA1CA2CYP3A4MAPTCES2 | |
| SCHEMBL989137 | 0.68 | MEN1 (0.39) | HPGDMEN1KMT2ACA1CA2 | |
| SCHEMBL10860644 | 0.68 | MEN1 (0.38) | MEN1KMT2ACA1CA2CA9 | |
| SCHEMBL4101706 | 0.68 | CA1 (0.39) | MEN1KMT2ACA1CA2CYP1A2 | |
| SCHEMBL11530943 | 0.67 | MAOB (0.50) | CYP1A2CYP2D6CYP2C19MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015370-B1 | DIPHOSPHONATE OR PHOSPHATE-PHOSPHONATE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1983-01-12 | — | — | EP | disclosed |
| US-4309364-A | Diphosphonates | SYMPHAR S.A. (CH) | 1982-01-05 | — | — | US | disclosed |
| EP-0015370-A1 | Diphosphonate or phosphate-phosphonate derivatives and pharmaceutical compositions containing them | SYMPHAR S.A. (CH) | 1980-09-17 | — | — | EP | disclosed |