SCHEMBL11236855

SCHEMBL11236855

CO[PH](=O)Oc1ccc(Cl)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.42
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA9 Q16790 1/20 0.38
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
MAPT P10636 1/20 0.37
CYP2C19 P33261 1/20 0.37
PPARA Q07869 1/20 0.37
MAOB P27338 3/20 0.35
MAOA P21397 2/20 0.35
MMP13 P45452 1/20 0.35
LMNA P02545 1/20 0.35
CYP2A6 P11509 1/20 0.35
PTGS2 P35354 3/20 0.34
NFE2L2 Q16236 1/20 0.34
POLB P06746 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4408434 0.86 MEN1 (0.43) HPGDMEN1KMT2ACA1CA2
SCHEMBL2895268 0.80 ACHE (0.48) MEN1KMT2ACA1CA2CA9
SCHEMBL673284 0.77 CA4 (0.46) HPGDCA1CA2CA9MAPT
SCHEMBL28946041 0.76 CA4 (0.44) HPGDCA1CA2CA9MAPT
Water SCHEMBL7651793 0.76 CA4 (0.44) HPGDCA1CA2CA9MAPT
SCHEMBL28946021 0.76 CA4 (0.44) HPGDCA1CA2CA9MAPT
SCHEMBL28946015 0.76 CA4 (0.44) HPGDCA1CA2CA9MAPT
SCHEMBL28946013 0.76 CA4 (0.44) HPGDCA1CA2CA9MAPT
SCHEMBL11213513 0.75 HPGD (0.36) HPGDMEN1KMT2ACA1CA2
SCHEMBL8628169 0.74 PTGS2 (0.47) PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4318783-A Process for the preparation of optionally substituted benzaldehyde dialkyl acetals BAYER AKTIENGESELLSCHAFT (DE) 1982-03-09 US disclosed