Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 14/20 | 0.49 |
| ▸ | RARB | P10826 | 7/20 | 0.47 |
| ▸ | RARG | P13631 | 7/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.36 |
| ▸ | RXRB | P28702 | 4/20 | 0.35 |
| ▸ | RARA | P10276 | 5/20 | 0.34 |
| ▸ | RXRG | P48443 | 3/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13668260 | 0.91 | RXRA (0.46) | RXRARARBRARGFTORXRB | |
| SCHEMBL9859988 | 0.89 | RXRA (0.60) | RXRARARBRARGRXRBRARA | |
| SCHEMBL8851470 | 0.79 | RXRA (0.49) | RXRARARBRARGRXRBRARA | |
| SCHEMBL13668272 | 0.79 | FTO (0.46) | RXRARARBRARGFTOAKR1B1 | |
| SCHEMBL11258404 | 0.78 | RXRA (0.35) | RXRARARBRARGRXRBRARA | |
| SCHEMBL17968225 | 0.78 | RXRA (0.49) | RXRARARBRARGRXRBRARA | |
| SCHEMBL13668361 | 0.77 | RXRA (0.52) | RXRARARBRARGRXRBRARA | |
| SCHEMBL16812205 | 0.77 | FTO (0.42) | RXRARARBRARGFTOAKR1B1 | |
| SCHEMBL13668270 | 0.77 | RXRA (0.36) | RXRARARBRARGRXRBRARA | |
| SCHEMBL7223558 | 0.76 | RXRA (0.71) | RXRARARBRARGRXRBRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326055-A | ANTITUMOR AGENTS, SKIN DISORDERS, RHEUMATIC DISEASES | HOFFMANN-LA ROCHE INC. (US) | 1982-04-20 | — | — | US | disclosed |
| EP-0002742-B1 | STILBENE DERIVATIVES, THEIR PREPARATION AND MEDICINES CONTAINING THESE STILBENE DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-04-14 | — | — | EP | disclosed |
| EP-0002742-A1 | Stilbene derivatives, their preparation and medicines containing these stilbene derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1979-07-11 | — | — | EP | disclosed |