Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11160967 | 0.84 | DRD1 (0.47) | CYP2D6DRD1DRD5POLB | |
| SCHEMBL11169221 | 0.84 | MEN1 (0.39) | SIGMAR1MEN1KMT2APOLB | |
| SCHEMBL11214359 | 0.83 | KCNH2 (0.46) | SIGMAR1 | |
| SCHEMBL11160646 | 0.79 | GAA (0.47) | MEN1KMT2A | |
| SCHEMBL11214362 | 0.78 | LMNA (0.40) | HRH1HRH3MEN1KMT2APOLB | |
| SCHEMBL11167197 | 0.77 | ALDH1A1 (0.45) | MEN1KMT2APOLB | |
| Bromide SCHEMBL11215989 | 0.77 | HRH3 (0.41) | CYP2D6HRH1HRH3SIGMAR1DRD1 | |
| Fumaric Acid SCHEMBL11169294 | 0.77 | MEN1 (0.43) | CYP2D6HTR1ADRD1DRD5MEN1 | |
| Fumaric Acid SCHEMBL11169280 | 0.77 | MEN1 (0.43) | CYP2D6HTR1ADRD1DRD5MEN1 | |
| SCHEMBL11162258 | 0.75 | HTR6 (0.44) | DRD1DRD5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0080012-A1 | 6-Chloro-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, its acid addition salts and its use as an intermediate | SMITHKLINE BECKMAN CORPORATION (US) | 1983-06-01 | — | — | EP | disclosed |
| US-4265890-A | ANTIPSYCHOTIC, ANTIEMETICS | SMITHKLINE CORPORATION (US) | 1981-05-05 | — | — | US | disclosed |
| EP-0007070-A1 | 2,3,4,5-Tetrahydro-1H-3-Benzazepines, process for their production and pharmaceutical compositions having dopamine receptor blocking activity | SMITHKLINE BECKMAN CORPORATION (US) | 1980-01-23 | — | — | EP | disclosed |