Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28396664 | 0.89 | ADRB1 (0.71) | ADRB1KDM4EALDH1A1PLA2G1BRAB9A | |
| SCHEMBL18950672 | 0.86 | DRD2 (0.68) | ADRB1HTR1ADRD2DRD3DRD4 | |
| SCHEMBL1825806 | 0.79 | ADRB1 (0.65) | ADRB1KDM4EALDH1A1PLA2G1BRAB9A | |
| SCHEMBL30407939 | 0.79 | ADRB1 (0.65) | ADRB1KDM4EALDH1A1PLA2G1BRAB9A | |
| SCHEMBL19212308 | 0.78 | ADRB1 (0.59) | ADRB1KDM4EALDH1A1PLA2G1BRAB9A | |
| SCHEMBL2096393 | 0.78 | ADRB1 (0.59) | ADRB1KDM4EALDH1A1PLA2G1BRAB9A | |
| SCHEMBL424507 | 0.78 | DRD2 (0.75) | ADRB1KDM4EALDH1A1PLA2G1BRAB9A | |
| SCHEMBL9362625 | 0.78 | NOTUM (0.43) | ADRB1KDM4EALDH1A1RAB9ALMNA | |
| SCHEMBL9655124 | 0.77 | ADRB1 (0.63) | ADRB1KDM4EALDH1A1PLA2G1BRAB9A | |
| SCHEMBL10893618 | 0.77 | ADRB1 (0.63) | ADRB1KDM4EALDH1A1PLA2G1BRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0042570-B1 | 20-DEOXYROSARAMICIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORPORATION (US) | 1983-10-19 | — | — | EP | disclosed |
| EP-0042570-A1 | 20-Deoxyrosaramicin derivatives, process for their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1981-12-30 | — | — | EP | disclosed |
| US-4279896-A | Novel 20-imino macrolide antibacterial agents | SCHERING CORPORATION (US) | 1981-07-21 | — | — | US | disclosed |