Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 4/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MPI | P34949 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10932003 | 0.99 | ADORA1 (0.44) | ADORA1CHEK1DAPK3LTKMAPK8 | |
| SCHEMBL10935078 | 0.83 | HDAC4 (0.32) | ADAMTS5 | |
| SCHEMBL10937070 | 0.83 | POLB (0.36) | ALDH1A1LMNAMAPTNPC1POLB | |
| SCHEMBL10933516 | 0.81 | GRM4 (0.44) | ALDH1A1LMNAGAAMAPTNPC1 | |
| SCHEMBL10933747 | 0.81 | NPY5R (0.37) | ALDH1A1MAPTPOLBHPGDALOX15 | |
| SCHEMBL10933430 | 0.79 | NPY5R (0.45) | KDM4EALDH1A1GAAMAPTNPC1 | |
| SCHEMBL10933216 | 0.78 | NPY5R (0.48) | LIMK1CDK5DYRK1ACLK4DYRK1B | |
| SCHEMBL11220773 | 0.78 | ADAMTS5 (0.31) | ADAMTS5 | |
| SCHEMBL11221756 | 0.78 | GRM4 (0.43) | RAB9AL3MBTL1NPY5R | |
| SCHEMBL10935069 | 0.78 | NPY5R (0.39) | ALDH1A1LMNAMAPTNPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4358407-A | Benzothiazine derivatives | YOSHITOMI PHARMACEUTICAL INDUSTRIES LTD. (JP) | 1982-11-09 | — | — | US | disclosed |
| EP-0042435-A1 | BENZOTHIAZINE DERIVATIVES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1981-12-30 | — | — | EP | disclosed |