Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 12/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | VDR | P11473 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4221973 | 0.86 | MAPT (0.47) | ALDH1A1GLAVDRLMNAMAPT | |
| SCHEMBL11224784 | 0.84 | PTGDR2 (0.59) | ALDH1A1GLAVDRMAPTSMN1; SMN2 | |
| SCHEMBL567908 | 0.84 | ALDH1A1 (0.49) | ABCB1ALDH1A1GLAKMT2AVDR | |
| SCHEMBL568467 | 0.84 | ALDH1A1 (0.49) | ABCB1ALDH1A1GLAKMT2AVDR | |
| SCHEMBL1043148 | 0.83 | PKM (0.49) | ABCB1ALDH1A1GLAKMT2ALMNA | |
| SCHEMBL11101150 | 0.83 | DRD4 (0.41) | ALDH1A1GLAKMT2AVDRSMN1; SMN2 | |
| SCHEMBL10527858 | 0.83 | MCHR1 (0.44) | ALDH1A1GLAKMT2AVDRLMNA | |
| SCHEMBL7968230 | 0.83 | ABCB1 (0.51) | ABCB1ALDH1A1GLASRCTGFBR1 | |
| SCHEMBL7968232 | 0.83 | ABCB1 (0.51) | ABCB1ALDH1A1GLASRCTGFBR1 | |
| SCHEMBL7968234 | 0.83 | ABCB1 (0.51) | ABCB1ALDH1A1GLASRCTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005610-B1 | 1-(HETEROCYCLYLALKYL)-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONES, THEIR PREPARATION, THEIR PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS BETA-ADRENERGIC RECEPTOR BLOCKERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-12-15 | — | — | EP | disclosed |
| US-4181802-A | ADRENERGIC BLOCKING AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-01-01 | — | — | US | disclosed |
| EP-0005610-A2 | 1-(Heterocyclylalkyl)-1,3-dihydro-2H-benzimidazol-2-ones, their preparation, their pharmaceutical compositions and their use as beta-adrenergic receptor blockers | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-11-28 | — | — | EP | disclosed |