SCHEMBL112184

SCHEMBL112184

OB(O)c1cncc2ccccc12

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCZ Q05513 1/20 0.42
ADRA2A P08913 1/20 0.41
ADRA2B P18089 1/20 0.41
ADRA2C P18825 1/20 0.41
ADRA1A P35348 1/20 0.41
CYP11B2 P19099 9/20 0.39
CYP11B1 P15538 8/20 0.39
KDM4E B2RXH2 2/20 0.38
MAPT P10636 1/20 0.38
MAPKAPK2 P49137 1/20 0.38
CYP3A4 P08684 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2B6 P20813 1/20 0.38
CYP2C19 P33261 1/20 0.38
ERN1 O75460 2/20 0.38
GPR3 P46089 1/20 0.38
CYP17A1 P05093 1/20 0.37
SLC22A12 Q96S37 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29694473 1.00 PRKCZ (0.42) PRKCZADRA2AADRA2BADRA2CADRA1A
Hydrochloric Acid SCHEMBL951403 0.98 PRKCZ (0.41) PRKCZADRA2AADRA2BADRA2CADRA1A
Hydrochloric Acid SCHEMBL29951532 0.98 PRKCZ (0.41) PRKCZADRA2AADRA2BADRA2CADRA1A
SCHEMBL29951405 0.81 KDM4E (0.44) KDM4EMAPTMAPKAPK2CYP3A4CYP1A2
SCHEMBL1942375 0.79 PRKCZ (0.39) PRKCZADRA2AADRA2BADRA2CADRA1A
SCHEMBL29954125 0.76 KDM4E (0.58) PRKCZKDM4EMAPTMAPKAPK2CYP3A4
SCHEMBL419728 0.76 KDM4E (0.58) PRKCZKDM4EMAPTMAPKAPK2CYP3A4
SCHEMBL782732 0.76 CYP11B2 (0.34) PRKCZADRA2AADRA2BADRA2CADRA1A
Hydrochloric Acid SCHEMBL2548053 0.75 KDM4E (0.56) PRKCZKDM4EMAPTMAPKAPK2CYP3A4
SCHEMBL17981376 0.75 CYP1A2 (0.38) KDM4EMAPTCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 665 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113957441-A Etching solution and preparation method and application thereof 光华科学技术研究院(广东)有限公司 2022-01-21 CN claimed
EP-3746436-B1 FUSED RING COMPOUNDS HOFFMANN LA ROCHE (CH) 2026-05-20 EP disclosed
US-20260124222-A1 ISOTHIAZOLYLCARBOXAMIDE COMPOUNDS AND THEIR USE IN THERAPY HOTSPOT THERAPEUTICS INC (US) 2026-05-07 US disclosed
US-20260124309-A1 STAT6 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2026-05-07 US disclosed
US-20260125400-A1 TYK2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2026-05-07 US disclosed
US-12612424-B2 HPK1 inhibitors and uses thereof REGOR PHARMACEUTICALS, INC. (US) 2026-04-28 US disclosed
EP-4695230-A1 PROTEASE INHIBITORS AND USES THEREOF Westlake Pharmaceuticals (Hangzhou) Co., Ltd. (CN) 2026-02-18 EP disclosed
US-12516059-B2 Pyrazolopyridine compounds and uses thereof INCYTE CORPORATION (US) 2026-01-06 US disclosed
US-12509424-B2 Compound and composition as PDGF receptor kinase inhibitor NIPPON SHINYAKU CO., LTD. (JP) 2025-12-30 US disclosed
US-12441702-B2 Substituted 4-benzyl and 4-benzoyl piperidine derivates CEPHALON LLC (US) 2025-10-14 US disclosed
CN-1315830-A Method for treating anxiety disorders LILLY CO ELI (US) 2001-10-03 CN disclosed
WO-2001053268-A2 INDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND THEIR USE FOR MEDIATING OR INHIBITING CELL PROLIFERATION AGOURON PHARMACEUTICALS, INC. (US) 2001-07-26 WO disclosed
US-6242450-B1 SUBSTITUTED PIPERIDINES ELI LILLY AND COMPANY 2001-06-05 US disclosed
US-6107307-A PSYCHOLOGICAL DISORDERS ELI LILLY AND COMPANY (US) 2000-08-22 US disclosed
WO-2000006082-A2 TREATMENT OF ANXIETY DISORDERS ELI LILLY AND COMPANY (US) 2000-02-10 WO disclosed
WO-2000006166-A1 5-HT1F ANTAGONISTS ELI LILLY AND COMPANY (US) 2000-02-10 WO disclosed
EP-0976746-A1 5-HT1F antagonists ELI LILLY AND COMPANY (US) 2000-02-02 EP disclosed
EP-0976747-A2 Use of 5HT-1F receptor antagonists for treating anxiety disorders ELI LILLY AND COMPANY (US) 2000-02-02 EP disclosed
EP-0969005-A1 Azabicyclic inhibitors of serotonin reuptake ELI LILLY AND COMPANY (US) 2000-01-05 EP disclosed
WO-1999065492-A1 INHIBITION OF SEROTONIN REUPTAKE ELI LILLY AND COMPANY (US) 1999-12-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260125400-A1 TYK2 DEGRADERS AND USES THEREOF TYK2, CSNK2A1, CSNK2A2 PRKCZ 1337/4885ADRA2A 1952/4885ADRA2B 2188/4885
US-12612424-B2 HPK1 inhibitors and uses thereof NEK11, NEK1, CSNK1A1 PRKCZ 188/4885ADRA2A 855/4885ADRA2B 1151/4885
US-12441702-B2 Substituted 4-benzyl and 4-benzoyl piperidine derivates FASN, CES1, FADS2 PRKCZ 2868/4885ADRA2A 1994/4885ADRA2B 1440/4885
US-20260124309-A1 STAT6 DEGRADERS AND USES THEREOF STAT6, NCOR2, NCOR1 PRKCZ 2252/4885ADRA2A 608/4885ADRA2B 403/4885
US-12509424-B2 Compound and composition as PDGF receptor kinase inhibitor PDGFRA, PDGFRB, PDGFA PRKCZ 98/4885ADRA2A 1747/4885ADRA2B 1384/4885
US-20260124222-A1 ISOTHIAZOLYLCARBOXAMIDE COMPOUNDS AND THEIR USE IN THERAPY MALT1, BCL6, BCL6B PRKCZ 132/4885ADRA2A 4505/4885ADRA2B 4597/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.